# Traditional Chinese Medicine Formulae QY305 Reducing Cutaneous Adverse Reaction and Diarrhea by its Nanostructure

## TL;DR

A traditional Chinese medicine formula called QY305 reduces skin and gut side effects caused by certain drugs, with its nanostructure playing a key role.

## Contribution

The study identifies a nanostructure within QY305 as the key pharmacodynamic component responsible for its therapeutic effects.

## Key findings

- QY305 reduces cutaneous adverse reactions and diarrhea in both human and animal models.
- The nanostructure N-QY305 is more potent than the full QY305 formula in reducing adverse effects.
- The nanostructure N-QY305 is proposed as the 'King' component of the TCM formula.

## Abstract

Traditional Chinese medicine (TCM) is widely used in clinical practice, including skin and gastrointestinal diseases. Here, a potential TCM QY305 (T‐QY305) is reported that can modulate the recruitment of neutrophil in skin and colon tissue thus reducing cutaneous adverse reaction and diarrhea induced by epidermal growth factor receptor inhibitors (EGFRIs). On another hand, the T‐QY305 formula, through regulating neutrophil recruitment features would highlight the presence of N‐QY305, a subunit nanostructure contained in T‐QY305, and confirm its role as potentially being the biomaterial conferring to T‐QY305 its pharmacodynamic features. Here, the clinical records of two patients are analyzed expressing cutaneous adverse reaction and demonstrate positive effect of T‐QY305 on the simultaneous inhibition of both cutaneous adverse reaction and diarrhea in animal models. The satisfying results obtained from T‐QY305, lead to further process to the isolation of N‐QY305 from T‐QY305, in order to demonstrate that the potency of T‐QY305 originates from the nanostructure N‐QY305. Compared to T‐QY305, N‐QY305 exhibits higher potency upon reducing adverse reactions. The data represent a promising candidate for reducing cutaneous adverse reaction and diarrhea, meanwhile proposing a new strategy to highlight the presence of nanostructures being the “King” of Chinese medicine formula as the pharmacodynamic basis.

Chinese medicine formula T‐QY305 can reduce cutaneous adverse reaction and diarrhea induced by EGFRIs both in human and animals, which corresponds to “Jun”‐“Chen”‐“Zuo”‐“Shi” TCM theory. Meanwhile a new strategy is proposed to highlight the presence of nanostructure N‐QY305 being the “King” of Chinese medicine formula as the pharmacodynamic basis.