Expression of Concern: Minocycline Suppresses Interleukine-6, Its Receptor System and Signaling Pathways and Impairs Migration, Invasion and Adhesion Capacity of Ovarian Cancer Cells: In Vitro and In Vivo Studies

Abstract
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TopicsBioactive Compounds and Antitumor Agents · Cancer, Stress, Anesthesia, and Immune Response · Tea Polyphenols and Effects
Following the publication of this article [1], concerns were raised regarding the results presented in multiple figures. Specifically,
The corresponding author stated that none of the original data underlying this article remain available.
The corresponding author acknowledged that the 24 h β-actin panel in Fig 5B is incorrect and provided an updated figure published with this notice. They clarified that the β-actin panels in Fig 4A and 4B and within Fig 8B were reused as the blots were stripped and reprobed. In the absence of original images underlying these figures, these issues cannot be fully resolved.
The corresponding author stated that images from this article [1] were inadvertently reused in the other article [2], and they asserted that the PLOS ONE article presents the correct data.
The PLOS ONE Editors issue this Expression of Concern due to the number of panels and figures affected and the absence of original data, which raise concerns regarding the overall reliability of the data presented in the original article.
The reference list from the paper itself. Each links out to its DOI / PubMed record.
- 1Ataie-Kachoie P, Morris DL, Pourgholami MH (2013) Minocycline Suppresses Interleukine-6, Its Receptor System and Signaling Pathways and Impairs Migration, Invasion and Adhesion Capacity of Ovarian Cancer Cells: In Vitro and In Vivo Studies. P Lo S ONE 8(4): e 60817. doi: 10.1371/journal.pone.0060817 23593315 PMC 3620477 · doi ↗ · pubmed ↗
- 2Parvin Ataie-Kachoie, Samina Badar, Morris David L., Mohammad H. Pourgholami; Minocycline Targets the NF-κB Nexus through Suppression of TGF-β1-TAK 1-IκB Signaling in Ovarian Cancer. Mol Cancer Res 1 October 2013; 11 (10): 1279–1291. 10.1158/1541-7786.MCR-13-023923858099 · doi ↗ · pubmed ↗
