# Comparing spinal anesthesia approaches for transurethral lithotripsy in patients with proximal ureteral stones: A randomized clinical trial of bupivacaine alone versus bupivacaine with fentanyl

**Authors:** Hossein Khoshrang, Reza Shahrokhi Damavand, Hamidreza Nasseh, Ardalan Akhavan Tavakoli, Samaneh Esmaeili, Mehdi Ghaffari, Maryam Shakiba

PMC · DOI: 10.25122/jml-2023-0109 · Journal of Medicine and Life · 2023-10-01

## TL;DR

This study compares spinal anesthesia techniques for kidney stone surgery, finding that adding fentanyl to bupivacaine reduces patient movement during the procedure.

## Contribution

The study demonstrates that adding fentanyl to bupivacaine in spinal anesthesia reduces retropulsion during transurethral lithotripsy.

## Key findings

- Adding fentanyl to bupivacaine significantly reduced retropulsion during surgery.
- The motor block duration was longer with bupivacaine plus fentanyl.
- No significant differences were found in sensory block or pain scores between groups.

## Abstract

Despite the benefits of spinal anesthesia and the preference of anesthesiologists for this technique, it is less accepted by urologists due to the proximity of the stone place in the ureter and the possibility of pain, restlessness, and occasional movements of the patient during surgery. The current study investigated the success of bupivacaine plus intrathecal fentanyl in patients undergoing transurethral lithotripsy (TUL). In this randomized clinical trial, from April 2021 to September 2021, 54 patients with proximal urolithiasis candidates for TUL were enrolled. Patients were randomly categorized into two groups: group A received bupivacaine 10 mg and 0.5 ml of normal saline, while group B received bupivacaine 10 mg with 0.5 ml (25µg) of intrathecal fentanyl. According to our findings, about 74% of the patients were men, and the mean age of the patients was 66.14±22.46 years. The onset time of the sensory block, sensory block level, pain score, degree of relaxation, depth of the motor block, occurrence of anesthesia complications, oxygen saturation, and mean arterial blood pressure were not significantly different between the two groups. However, the duration of the motor block in group B was longer than in group A (p<0.001). Also, retropulsion was observed only in five patients (18.5%) in group A, significantly higher than in group B (p=0.019). Bupivacaine with fentanyl 25µg provided adequate spinal anesthesia with lower retropulsion in patients with urolithiasis who are candidates for TUL.

## Linked entities

- **Chemicals:** bupivacaine (PubChem CID 2474), fentanyl (PubChem CID 3345)
- **Diseases:** urolithiasis (MONDO:0024647)

## Full-text entities

- **Diseases:** pain (MESH:D010146), ureteral stones (MESH:D014515), proximal urolithiasis (MESH:D052878), motor block (MESH:D006327)
- **Chemicals:** Bupivacaine (MESH:D002045), oxygen (MESH:D010100), fentanyl (MESH:D005283)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

34 references — full list in the complete paper: https://tomesphere.com/paper/PMC10835565/full.md

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Source: https://tomesphere.com/paper/PMC10835565