# Transoral balloon kyphoplasty in a myeloma patient with painful osseous destruction of the corpus vertebrae axis

**Authors:** Julian Ramin Andresen, Harald Widhalm, Reimer Andresen

PMC · DOI: 10.1093/jscr/rjae009 · 2024-01-30

## TL;DR

This paper describes a successful use of transoral balloon kyphoplasty to treat a myeloma patient with a fractured vertebra, resulting in pain relief.

## Contribution

The novel application of transoral balloon kyphoplasty for myeloma-related vertebral fractures is presented.

## Key findings

- Transoral balloon kyphoplasty was successfully used in a myeloma patient with C2 vertebral body fracture.
- The procedure led to significant clinical improvement and pain minimization in the patient.

## Abstract

Multiple myeloma is the most common primary malignant disease of the spine, which can lead to pathological fractures with consecutive instability and immobilizing pain, due to osseous destruction of individual vertebral bodies. The different surgical care is challenging, although good stabilization should be achieved if possible. The resulting blocking of micro-movements leads to pain minimization. However, this is a symptomatic therapy and does not address the primary disease. In the following, we report on successful transoral balloon kyphoplasty for the treatment of myeloma-related osteolysis with a pathological fracture of vertebral body C2, which led to a significant clinical improvement.

## Linked entities

- **Diseases:** Multiple myeloma (MONDO:0009693)

## Full-text entities

- **Diseases:** BKP (MESH:D054549), trauma (MESH:D014947), MM (MESH:D009101), osseous lesion (MESH:D000070896), instability of the vertebral body C2 lesion (OMIM:217000), breast cancer (MESH:D001943), monoclonal gammopathy of undetermined significance (MESH:D008998), weight loss (MESH:D015431), osteopenic destruction (MESH:C567172), tumour (MESH:D009369), leakage (MESH:D003763), hypercalcaemia syndrome (MESH:D013577), lung cancer (MESH:D008175), osteolysis (MESH:D010014), destruction (MESH:D008105), chronic infections (MESH:D000088562), inflammation in the nasopharynx (MESH:D009302), fracture (MESH:D050723), thyroid carcinoma (MESH:D013964), pathological fracture (MESH:D005598), Pain (MESH:D010146), vertebral metastases (MESH:D009362), fracture of vertebral body (MESH:C536543), hyperextension (MESH:C563315), infection (MESH:D007239), cement leakage (MESH:C563017), oedema (MESH:C536897), obesity (MESH:D009765), lesion (MESH:D009059), spine (MESH:D016135), Spinal Instability Neoplastic (MESH:D013125), angioma (MESH:D006391), aneurysmal bone cyst (MESH:D017824), anaemia (MESH:D000743), renal insufficiency (MESH:D051437)
- **Chemicals:** Zometa (MESH:D000077211), 18F-Fluordesoxyglucose (-), PMMA (MESH:D019904), Darzalex (MESH:C556306), Xgeva (MESH:D000069448), Cefazolin (MESH:D002437), 18F-FDG (MESH:D019788)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Mutations:** A 19-G

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC10832603/full.md

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Source: https://tomesphere.com/paper/PMC10832603