# Hamartoma of the soft palate: Case report and review of literature

**Authors:** El Krimi Zineb, Saoutarrih Badr, Douimi Loubna, Bijou Walid, Mahtar Mohamed

PMC · DOI: 10.1016/j.ijscr.2024.109281 · 2024-01-20

## TL;DR

This paper reports a rare case of hamartoma in a newborn's soft palate and discusses its diagnosis and successful surgical treatment.

## Contribution

The paper contributes a new clinical case report of a rare soft palate hamartoma in a newborn, adding to the limited existing literature.

## Key findings

- Hamartoma of the soft palate is rare and can cause serious complications due to its location.
- Surgical removal via a transoral approach leads to excellent prognosis with no recurrence.
- Diagnosis relies on histopathology, with imaging used to assess lesion extent.

## Abstract

Hamartoma is a tumor-like malformation that represents a focal proliferation of normal cells. Hamartoma of the soft palate is a rare entity, which can lead to serious, life-threatening clinical manifestations, given its anatomical location. However, if properly treated surgically, their prognosis is excellent.

The literature reports very few similar cases. So, we report a case of hamartoma of the soft palate, which presented as a sessile velar outgrowth arising on the midline of a 12-day-old newborn. The final diagnosis was based on histopathology. The patient was treated surgically and had excellent evolution.

Clinical Discussion.

Clinical examination shows hamartomas of the palate to be polyploid lesions, with a firm surface. A CT scan and magnetic resonance imaging (MRI) are indicated to establish the extent of the tumor. The diagnosis of certainty is determined by a histopathological examination. The only treatment is surgery, generally via the transoral approach. Prognosis is excellent.

Hamartomas of the palate are diagnosed histologically, with imaging being of great help in assessing extension, and their therapeutic management is exclusively surgical.

The prognosis after successful surgery is practically always good, with no recurrence.

•Hamartoma is a tumor-like malformation, comprising a disorganized combination of mature tissues gradually increasing in volume.•Hamartomas of the soft palate remain a rare entity, whose anatomical location may lead to clinically serious complications.•The palate hamartoma is clinically described as a polyploid lesion.•CT scan and magnetic resonance imaging are indicated to determine the extent of the lesion. The diagnosis of certainty is determined by histopathological examination.•Surgery, usually transoral, is the only treatment available. Its prognosis is excellent.

Hamartoma is a tumor-like malformation, comprising a disorganized combination of mature tissues gradually increasing in volume.

Hamartomas of the soft palate remain a rare entity, whose anatomical location may lead to clinically serious complications.

The palate hamartoma is clinically described as a polyploid lesion.

CT scan and magnetic resonance imaging are indicated to determine the extent of the lesion. The diagnosis of certainty is determined by histopathological examination.

Surgery, usually transoral, is the only treatment available. Its prognosis is excellent.

## Linked entities

- **Diseases:** hamartoma (MONDO:0006499)
- **Species:** Homo sapiens (taxon 9606)

## Full-text entities

- **Genes:** SMAD4 (SMAD family member 4) [NCBI Gene 4089] {aka DPC4, JIP, MADH4, MYHRS}, BMPR1A (bone morphogenetic protein receptor type 1A) [NCBI Gene 657] {aka 10q23del, ACVRLK3, ALK-3, ALK3, BMPR-1A, CD292}, PTEN (phosphatase and tensin homolog) [NCBI Gene 5728] {aka 10q23del, BZS, CWS1, DEC, GLM2, MHAM}, CDK7 (cyclin dependent kinase 7) [NCBI Gene 1022] {aka CAK, CAK1, CDKN7, HCAK, MO15, STK1}
- **Diseases:** Congenital tumors of the oral cavity (MESH:D009062), micro-phthalmia (MESH:C536681), vascular malformations (MESH:D054079), congenital tumors (MESH:D009369), developmental defects (MESH:D000094602), swelling (MESH:D004487), tumor of the accessory salivary glands (MESH:D012468), cleft palate (MESH:D002972), tuberous sclerosis (MESH:D014402), dyspnea (MESH:D004417), malformations (MESH:C564254), Cowden's syndrome (MESH:D006223), behavioral disorders (MESH:D001523), lymphangioma (MESH:D008202), hypothalamic hamartomas (MESH:C537158), Hamartoma of the soft palate (MESH:D006222), PRESENTATION (MESH:D001946), teratoma (MESH:D013724), congenital epulis (MESH:D005887), visual disturbances (MESH:D014786), congenital disorder (MESH:D009358), lesion (MESH:D009059), dysphagia (MESH:D003680), hemangioma (MESH:D006391), bleeding (MESH:D006470), seizures (MESH:D012640), Peutz-Jeghers syndrome (MESH:D010580), leiomyoma (MESH:D007889)
- **Chemicals:** oxygen (MESH:D010100)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC10832450/full.md

---
Source: https://tomesphere.com/paper/PMC10832450