# Positive outcomes with neoadjuvant chemotherapy in the management of colovesical fistula in cancer: a case report and literature review

**Authors:** Song Tang, Xinjun Li, Donghua Guo, Fan Zhuo

PMC · DOI: 10.3389/fphar.2023.1284316 · Frontiers in Pharmacology · 2024-01-15

## TL;DR

A 62-year-old man with colon cancer and a bladder fistula showed positive results after receiving neoadjuvant chemotherapy before surgery.

## Contribution

The paper introduces the innovative use of neoadjuvant chemotherapy for complex cancerous colovesical fistulas.

## Key findings

- Neoadjuvant chemotherapy significantly reduced the tumor and fistula size.
- Radical surgery was successfully performed with negative margins after chemotherapy.

## Abstract

Colovesical fistula (CVF) is usually developed from colonic diverticulitis, followed by tumor. Traditional surgery is usually completed in one or more stages. For complex cancerous CVF, radical resection is more difficult. We report a 62-year-old male patient diagnosed with sigmoid colon cancer combined with sigmoid vesical fistula. In the course of treatment, in addition to conventional surgery, neoadjuvant chemotherapy (NAC) was innovatively used. The sigmoid tumor and fistula were significantly shrunken. Radical surgery achieved negative margins.

## Linked entities

- **Diseases:** sigmoid colon cancer (MONDO:0001464)

## Full-text entities

- **Genes:** MLH1 (mutL homolog 1) [NCBI Gene 4292] {aka COCA2, FCC2, HNPCC, HNPCC2, LYNCH2, MLH-1}, GATA3 (GATA binding protein 3) [NCBI Gene 2625] {aka HDR, HDRS}, TP53 (tumor protein p53) [NCBI Gene 7157] {aka BCC7, BMFS5, LFS1, P53, TRP53}, KRT7 (keratin 7) [NCBI Gene 3855] {aka CK7, K2C7, K7, SCL}, PMS2 (PMS1 homolog 2, mismatch repair system component) [NCBI Gene 5395] {aka HNPCC4, LYNCH4, MLH4, MMRCS4, PMS-2, PMSL2}, MSH2 (mutS homolog 2) [NCBI Gene 4436] {aka COCA1, FCC1, HNPCC, HNPCC1, LCFS2, LYNCH1}, IL9 (interleukin 9) [NCBI Gene 3578] {aka HP40, IL-9, P40}, CD274 (CD274 molecule) [NCBI Gene 29126] {aka ADMIO5, B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1}, CDX2 (caudal type homeobox 2) [NCBI Gene 1045] {aka CDX-3, CDX2/AS, CDX3}, MSH6 (mutS homolog 6) [NCBI Gene 2956] {aka GTBP, GTMBP, HNPCC5, HSAP, LYNCH5, MMRCS3}, KRT20 (keratin 20) [NCBI Gene 54474] {aka CD20, CK-20, CK20, K20, KRT21}, BRAF (B-Raf proto-oncogene, serine/threonine kinase) [NCBI Gene 673] {aka B-RAF1, B-raf, BRAF-1, BRAF1, NS7, RAFB1}
- **Diseases:** anastomotic leakage (MESH:D057868), Sigmoid tumor (MESH:D012811), adenocarcinoma of the sigmoid colon (MESH:D003110), cervical cancer (MESH:D002583), trauma (MESH:D014947), lymph node metastasis (MESH:D008207), emphysematous cystitis (MESH:D041882), sepsis (MESH:D018805), Tumors (MESH:D009369), abscess (MESH:D000038), Sigmoid (MESH:D012810), adenomatous intraepithelial neoplasia (MESH:D002578), urinary tract infection (MESH:D014552), tenderness (MESH:D063806), fistula (MESH:D005402), metastasis (MESH:D009362), infection (MESH:D007239), rebound pain (MESH:D010146), adenocarcinoma (MESH:D000230), bleeding (MESH:D006470), abdominal mass (MESH:D000007), bladder cancer (MESH:D001749), CVF (MESH:D007412), sigmoid vesical fistula (MESH:D001747), colonic diverticulitis (MESH:D004239), Crohn's disease (MESH:D003424), colon cancer (MESH:D015179), hepatopulmonary metastases (MESH:D020065)
- **Chemicals:** oxaliplatin (MESH:D000077150), XELOX (MESH:C519688), fluorouracil (MESH:D005472), 22C3 (-), panitumumab (MESH:D000077544), calcium folinate (MESH:D002955)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Mutations:** V600E

## Full text

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## Figures

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## References

23 references — full list in the complete paper: https://tomesphere.com/paper/PMC10828894/full.md

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Source: https://tomesphere.com/paper/PMC10828894