# Mechanical sensor PDLIM5 promotes the osteogenesis of human adipose-derived stem cells through microfilament alterations

**Authors:** Yuchao Yang, Shutong Wu, Rongmei Qu, Congrong Wang, Jinyang Wang, Asmat Ullah Khan, You Pan, Wenqing Liu, Jinhui Zhu, Muhammad Akram Khan, Chujiang Xu, Jingxing Dai, Jun Ouyang

PMC · DOI: 10.1016/j.gendis.2023.06.001 · Genes & Diseases · 2023-07-11

## Full-text entities

- **Genes:** THY1 (Thy-1 cell surface antigen) [NCBI Gene 7070] {aka CD90, CDw90}, PDLIM5 (PDZ and LIM domain 5) [NCBI Gene 10611] {aka ENH, ENH1, L9, LIM}, ACTN1 (actinin alpha 1) [NCBI Gene 87] {aka BDPLT15}, SPP1 (secreted phosphoprotein 1) [NCBI Gene 6696] {aka BNSP, BSPI, ETA-1, OPN}, CD24 (CD24 molecule) [NCBI Gene 100133941] {aka CD24A}, RUNX2 (RUNX family transcription factor 2) [NCBI Gene 860] {aka AML3, CBF-alpha-1, CBFA1, CCD, CCD1, CLCD}, ITGB1 (integrin subunit beta 1) [NCBI Gene 3688] {aka CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA}, GAPDH (glyceraldehyde-3-phosphate dehydrogenase) [NCBI Gene 2597] {aka G3PD, GAPD, HEL-S-162eP}, PTPRC (protein tyrosine phosphatase receptor type C) [NCBI Gene 5788] {aka B220, CD45, CD45R, GP180, IMD105, L-CA}, ALPP (alkaline phosphatase, placental) [NCBI Gene 250] {aka ALP, PALP, PLAP, PLAP-1}, YAP1 (Yes1 associated transcriptional regulator) [NCBI Gene 10413] {aka COB1, YAP, YAP-1, YAP2, YAP65, YKI}, POTEF (POTE ankyrin domain family member F) [NCBI Gene 728378] {aka A26C1B, POTE2alpha, POTEACTIN}
- **Diseases:** bone defect (MESH:D001847), tumor (MESH:D009369), fracture (MESH:D050723), infection (MESH:D007239)
- **Chemicals:** ARS (MESH:C004468), 1H (-), CytoD (MESH:D015638)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Cell lines:** S2B — Homo sapiens (Human), Childhood T acute lymphoblastic leukemia, Cancer cell line (CVCL_1860), GM — Bombyx mori (Silk moth), Spontaneously immortalized cell line (CVCL_Z635), OS — Homo sapiens (Human), Osteosarcoma, Cancer cell line (CVCL_1E51), hASCs — Homo sapiens (Human), Somatic stem cell (CVCL_WG55)

## Full text

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## Figures

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## References

5 references — full list in the complete paper: https://tomesphere.com/paper/PMC10828594/full.md

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Source: https://tomesphere.com/paper/PMC10828594