# Managing Pulmonary Embolism With Right Ventricular Thrombus in In Vitro Fertilization-Related Pregnancy: A Clinical Insight

**Authors:** Saleh A Ba-shammakh, Eman A Al-zughali, Nashaat A Al-Shami, Ali H Al-Darobi, Hammam A Abuaisha, Shadi Karabsheh

PMC · DOI: 10.7759/cureus.51383 · Cureus · 2023-12-31

## TL;DR

This case study explores managing a high-risk blood clot in a pregnant patient after IVF, emphasizing careful treatment to protect both mother and fetus.

## Contribution

The paper presents a novel clinical approach to managing pulmonary embolism with right ventricular thrombus in IVF-related pregnancy.

## Key findings

- Conservative treatment with low-molecular-weight heparin improved the patient's condition without invasive procedures.
- Diagnostic challenges arose from overlapping symptoms of PE and typical pregnancy signs.
- A judicious approach balancing maternal and fetal risks was successfully implemented.

## Abstract

This case study provides an insightful examination of the management of high-risk pulmonary embolism (PE) in a 27-year-old pregnant patient following in vitro fertilization (IVF). Overlapping symptoms of PE and typical pregnancy manifestations, coupled with concerns about radiation exposure from diagnostic imaging, presented unique diagnostic challenges. Despite the heightened risk of thrombosis during pregnancy and elevated D-dimer levels, a conservative approach was strategically employed. This involved therapeutic anticoagulation using low-molecular-weight heparin, leading to significant patient improvement without the need for invasive interventions. This case highlights the imperative for a judicious yet proactive approach in managing PE among pregnant patients, meticulously considering both maternal and fetal health risks.

## Linked entities

- **Diseases:** pulmonary embolism (MONDO:0005279), thrombosis (MONDO:0000831)

## Full-text entities

- **Genes:** PROC (protein C, inactivator of coagulation factors Va and VIIIa) [NCBI Gene 5624] {aka APC, PC, PROC1, THPH3, THPH4}, CMPK1 (cytidine/uridine monophosphate kinase 1) [NCBI Gene 51727] {aka CK, CMK, CMPK, UMK, UMP-CMPK, UMPK}, F5 (coagulation factor V) [NCBI Gene 2153] {aka FVL, PCCF, RPRGL1, THPH2, fV}, MTHFR (methylenetetrahydrofolate reductase) [NCBI Gene 4524], SERPINC1 (serpin family C member 1) [NCBI Gene 462] {aka AT3, AT3D, ATIII, ATIII-R2, ATIII-T1, ATIII-T2}
- **Diseases:** venous thromboembolism (MESH:D054556), lupus anticoagulant (MESH:C531622), substance abuse (MESH:D019966), hypotension (MESH:D007022), stroke (MESH:D020521), heart palpitations (MESH:D006331), DVT (MESH:D020246), lower limb swelling (MESH:D038061), deaths (MESH:D003643), ANA (MESH:D007153), embolism (MESH:D004617), right bundle branch block (MESH:D002037), sinus tachycardia (MESH:D013616), PE (MESH:D011655), tricuspid regurgitation (MESH:D014262), right ventricular enlargement (MESH:D018497), dilated right ventricle (MESH:C535682), bleeding (MESH:D006470), PEs (MESH:D005413), intracardiac thrombi (MESH:C538262), edema (MESH:D004487), cardiac output (MESH:D002303), gestational hypothyroidism (MESH:D007037), IVF (MESH:C566179), chest pain (MESH:D002637), shortness of breath (MESH:D004417), heart thromboembolism (MESH:D013923), hypoxic (MESH:D002534), thrombophilia (MESH:D019851), maternal (MESH:D000079262), RHT (MESH:D013927), teratogenic effects (MESH:C535542), septum distortion (MESH:D006311), effusion (MESH:D000080324), fetal loss (MESH:D005315), pain (MESH:D010146)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Mutations:** G20210A, G1691A, C677T

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC10825887/full.md

## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC10825887/full.md

## References

27 references — full list in the complete paper: https://tomesphere.com/paper/PMC10825887/full.md

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Source: https://tomesphere.com/paper/PMC10825887