# Aldh2 deficiency plays a dual role in lung tumorigenesis and tumor progression

**Authors:** Hongjia Zhang, Xueqian Sun, Zhanming Li, Tingting Liu, Fang Zhang, Xinyu Meng, Kaimi Li, Jianhua Xu, Wei He, Bo Jing, Tong Wang, Na Ni, Beibei Sun, Feng Yao, Yadi Wu, Qi Wang, Jing Du, Eugene Y. Chin, Binhua P. Zhou, Ping Jiang, Lishun Wang, Jiong Deng

PMC · DOI: 10.1016/j.gendis.2023.04.030 · Genes & Diseases · 2023-06-24

## Full-text entities

- **Genes:** GPRC5A (G protein-coupled receptor class C group 5 member A) [NCBI Gene 9052] {aka GPCR5A, PEIG-1, RAI3, RAIG1, TIG1}, Aldh2 (aldehyde dehydrogenase 2, mitochondrial) [NCBI Gene 11669] {aka AHD-M1, ALDH-E2, ALDHI, Ahd-5, Ahd5}, Pecam1 (platelet/endothelial cell adhesion molecule 1) [NCBI Gene 18613] {aka Cd31, PECAM-1, Pecam}, Ptprc (protein tyrosine phosphatase receptor type C) [NCBI Gene 19264] {aka B220, CD45R, Cd45, L-CA, Ly-5, Lyt-4}, Scgb1a1 (secretoglobin, family 1A, member 1) [NCBI Gene 22287] {aka CC10, CC16, CCSP, PCB-BP, UG, UGB}, AP2B1 (adaptor related protein complex 2 subunit beta 1) [NCBI Gene 163] {aka ADTB2, AP105B, AP2-BETA, CLAPB1}, Cd34 (CD34 antigen) [NCBI Gene 12490], Sftpa1 (surfactant associated protein A1) [NCBI Gene 20387] {aka SP-A, Sftp-1, Sftp1}, Atxn1 (ataxin 1) [NCBI Gene 20238] {aka 2900016G23Rik, Atx1, Gm10786, Sca1}, Anxa5 (annexin A5) [NCBI Gene 11747] {aka Anx5, CPB-I}, ALDH2 (aldehyde dehydrogenase 2 family member) [NCBI Gene 217] {aka ALDH-E2, ALDHI, ALDM}, Gprc5a (G protein-coupled receptor, family C, group 5, member A) [NCBI Gene 232431] {aka Rai3, Raig1}
- **Diseases:** LUAD (MESH:D000077192), toxicity (MESH:D064420), LUSC (MESH:D002294), Cancer (MESH:D009369), lung cancer (MESH:D008175), BASCs (MESH:D000092423), ALDH2 deficiency (MESH:C564560), carcinogenesis (MESH:D063646), lung metastasis (MESH:D009362)
- **Chemicals:** Alcohol (MESH:D000438), ROS (-), H&E (MESH:D006371), glutathione (MESH:D005978), acetate (MESH:D000085), Acetaldehyde (MESH:D000079), ETOH (MESH:D000431), NNK (MESH:C016583), retinoic acid (MESH:D014212)
- **Species:** Nicotiana tabacum (American tobacco, species) [taxon 4097], Homo sapiens (human, species) [taxon 9606], Mus musculus (house mouse, species) [taxon 10090]
- **Mutations:** G>A
- **Cell lines:** shALDH2 — Homo sapiens (Human), Colon carcinoma, Cancer cell line (CVCL_A628), S1601 — Homo sapiens (Human), Finite cell line (CVCL_AK19), H1792 — Homo sapiens (Human), Lung adenocarcinoma, Cancer cell line (CVCL_1495), A549 — Homo sapiens (Human), Lung adenocarcinoma, Cancer cell line (CVCL_0023)

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## References

5 references — full list in the complete paper: https://tomesphere.com/paper/PMC10825233/full.md

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Source: https://tomesphere.com/paper/PMC10825233