# Bilateral Temporal Headache As the Presenting Symptoms for a Case of Graves’ Disease

**Authors:** Ahmad S Alsabban, Hisham M Bakri, Abeer Z Abduljabbar, Abdullah A Almesfer, Abdulkareem M Alturkistani

PMC · DOI: 10.7759/cureus.51344 · Cureus · 2023-12-30

## TL;DR

A patient with Graves' disease presented only with bilateral headaches, highlighting the rare connection between thyroid issues and headache symptoms.

## Contribution

This case report highlights a rare presentation of Graves' disease with headache as the sole symptom.

## Key findings

- Bilateral temporal headaches can be the only symptom of Graves' disease.
- Treatment for Graves' disease led to rapid headache relief in this patient.
- Physicians should consider thyroid disorders when evaluating unexplained headaches.

## Abstract

Headache is not typically a presenting symptom of Graves' disease. Only a few studies suggest hyperthyroidism can cause headaches, and the connection remains indeterminable. While some cases report hyperthyroidism presenting as a simple headache, it is not specific to Graves' disease. This report details a middle-aged male patient who visited a primary healthcare center with a two-month history of bilateral temporal headaches. He was initially diagnosed as a query case of temporal arteritis due to his age and affected area and was transferred to the emergency department for a comprehensive evaluation. After discussions with specialists and various laboratory tests and CT scans, he was diagnosed with Graves' disease. Treatment led to fast improvement and relief of his headaches. This case represents a rare instance of Graves' disease where the patient's sole complaint was a simple headache without any other symptoms. We advise doctors to consider diseases related to increased thyroid gland activity when dealing with headaches.

## Linked entities

- **Diseases:** Graves' disease (MONDO:0005364), temporal arteritis (MONDO:0008538)

## Full-text entities

- **Genes:** CYGB (cytoglobin) [NCBI Gene 114757] {aka HGB, NOD, STAP}, SLC17A5 (solute carrier family 17 member 5) [NCBI Gene 26503] {aka AST, ISSD, NSD, SD, SIALIN, SIASD}, TSHR (thyroid stimulating hormone receptor) [NCBI Gene 7253] {aka CHNG1, LGR3, hTSHR-I}
- **Diseases:** sweaty palms (MESH:C535620), vasospasm (MESH:D020301), swelling of the right eye (MESH:D005128), exophthalmos (MESH:D005094), tachycardia (MESH:D013610), temporal arteritis (MESH:D013700), Hyperthyroidism (MESH:D006980), thyroid hormone abnormalities (MESH:C566454), menorrhagia (MESH:D008595), sweating (MESH:D013543), primary headache disorders (MESH:D051270), palpitations (MESH:D006331), Coma (MESH:D003128), thyroid abnormality (MESH:D013959), action tremor (MESH:D014202), dyspnea on (MESH:D004417), Grave's disease (MESH:D006111), increased intracranial pressure (MESH:D019586), weight loss (MESH:D015431), subacute thyroiditis (MESH:D013968), Impression (MESH:D010985), fever (MESH:D005334), hyperemia (MESH:D006940), painless thyroiditis (MESH:D013966), migraine (MESH:D008881), blurred vision (MESH:D014786), oligomenorrhea (MESH:D009839), infertility (MESH:D007246), Graves' ophthalmopathy (MESH:D049970), meningitis (MESH:D008580), Headache Disorders (MESH:D020773), Headache (MESH:D006261), brain insult (MESH:D001927), tenderness (MESH:D063806), dizziness or B symptoms (MESH:D004244), OPD (MESH:C538089), autoimmune condition (MESH:D001327), eyelid retraction (MESH:D005141), decreased weight or appetite (MESH:D001068), anterior ischemic optic neuritis (MESH:D009902), lid lag (MESH:D020179), left eye redness (MESH:D005134), pain (MESH:D010146)
- **Chemicals:** methimazole (MESH:D008713), anti-thyroid medication (-), T4 (MESH:D013974), CO2 (MESH:D002245), gamma-aminobutyric acid (MESH:D005680), propranolol (MESH:D011433), iodine (MESH:D007455)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC10824503/full.md

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Source: https://tomesphere.com/paper/PMC10824503