# Atraumatic Fractures in Multi-Morbid Older Adults: A Series of Five Cases and Review of Literature

**Authors:** Shaimaa N Rohaiem, Basim F Khan, Ghadeer H Al-Julaih, Ahmed S Mohammedin

PMC · DOI: 10.7759/cureus.51333 · Cureus · 2023-12-30

## TL;DR

This paper presents five cases of atraumatic fractures in older adults with multiple health issues, highlighting their unusual symptoms and management challenges.

## Contribution

The study identifies four ATF categories and emphasizes the need for systemic approaches to manage multi-morbid patients at high fracture risk.

## Key findings

- All five cases involved frail females with osteotoxic medications and multi-morbidities.
- Three cases experienced fracture cascades, with symptoms including aseptic fever and sudden giveaway.
- Conservative management was used in most cases, with one undergoing hip hemiarthroplasty.

## Abstract

Atraumatic fractures (ATFs) are a fragility fracture subtype with occasional medicolegal issues. ATFs are defined as fractures because of a “low-energy mechanism that is usually considered incapable of producing a fracture.” They are an underreported disorder, with epidemiological variations. ATF phenomena were previously reported not only in older adults, but also in children, young adults, older adults, and animals.

This study is a short retrospective case series exploring atraumatic fractures in a tertiary care university hospital. Over a period of two years, a total of seven ATF cases were identified. However, only five fulfilled the inclusion criteria. Local causes of pathologic fractures (e.g., metastasis) and elder abuse or neglect were excluded. Comparison of the cases’ clinical profile, fracture profile, and management was done.

All five cases were frail females with significant osteotoxic burdens from medications and multi-morbidities. ATF presentations included typical (as pain) and atypical (as painless, loud crack, and sudden giveaway) symptomatology. One ATF had a coincident unexplained aseptic fever. Three cases had more than one fracture (fracture cascade), confirmed and followed up by x-rays. All the cases were managed conservatively except for one case that underwent hip hemiarthroplasty. Plans of care included managing the osteotoxic multi-morbidities burden, focusing on the whole body, not only on the fracture or bone. The study provided insights about challenges in presentations of ATF (as the bone fracture acute phase reaction: osteogenic aseptic fever). Risk factors are classically assumed to be osteoporosis, but it is usually systemic and multifactorial. A high risk of fracture warning sign could help decrease ATF occurrence or fracture cascades. Four ATF categories were detected to help healthcare systems identify high-risk patients and raise awareness among medical staff, families, and caregivers. Future studies of the at-risk groups are needed to understand ATF knowledge gaps, challenges, and the best treatments.

## Full-text entities

- **Genes:** PTH (parathyroid hormone) [NCBI Gene 5741] {aka FIH1, PTH1}, FGF23 (fibroblast growth factor 23) [NCBI Gene 8074] {aka ADHR, FGFN, HFTC2, HPDR2, HYPF, PHPTC}, ALB (albumin) [NCBI Gene 213] {aka FDAHT, HSA, PRO0883, PRO0903, PRO1341}
- **Diseases:** neurogenic bladder (MESH:D001750), Malnutrition (MESH:D044342), vascular dementia (MESH:D015140), Charcot's joint (MESH:D001177), ATF (MESH:D005334), Frailty (MESH:D000073496), and femur (MESH:D000092524), calcification (MESH:D002114), unexplained fracture (MESH:D013001), EAN (MESH:D058069), vitamin D deficiency (MESH:D014808), Fragility fractures (MESH:D005600), spina bifida (MESH:D016135), contractures (MESH:D003286), emphysema (MESH:D004646), hip fracture (MESH:D006620), Chronic kidney disease (MESH:D051436), femoral fracture (MESH:D005264), hyperparathyroidism (MESH:D006961), osteomalacia (MESH:D010018), Crohn's disease (MESH:D003424), Hypokinesia (MESH:D018476), paraplegia (MESH:D010264), Painless long-bone (MESH:D050398), spinal cord injury (MESH:D013119), knee osteoarthritis (MESH:D020370), sarcopenia (MESH:D055948), CAUTI (MESH:D014552), cysts (MESH:D003560), myalgia (MESH:D063806), Osteoporosis (MESH:D010024), Atraumatic fractures (MESH:D050723), malunion (MESH:D017759), fractures of the spine (MESH:D000092443), pathologic fractures (MESH:D005598), heart failure (MESH:D006333), dementia (MESH:D003704), displaced fracture (MESH:D006617), hemiplegia (MESH:D006429), anorexia nervosa (MESH:D000856), pain (MESH:D010146), bruise (MESH:D003288), APR (MESH:D000210), protein (MESH:D011488), osteomyelitis (MESH:D010019), convulsions (MESH:D012640), fatigue (MESH:D005221), CKD (MESH:D012080), ischemic heart disease (MESH:D017202), PEM (MESH:D011502), anorexia (MESH:D000855), metastasis (MESH:D009362), muscle weakness (MESH:D018908), polyneuropathy (MESH:D011115), malignancy (MESH:D009369), neurologic disorders (MESH:D009461), Osteogenic (MESH:D012516), abuse (MESH:D019966), Venous thromboembolic disorder (MESH:D054556), crack (MESH:D003387)
- **Chemicals:** phosphate (MESH:D010710), phosphorus (MESH:D010758), haloperidol (MESH:D006220), L-thyroxine (MESH:D013974), lispro insulin (MESH:D061268), bisoprolol (MESH:D017298), denosumab (MESH:D000069448), bisphosphonate (MESH:D004164), lactulose (MESH:D007792), calcium (MESH:D002118), phenobarbital (MESH:D010634), vitamin D3 (MESH:D002762), steroid (MESH:D013256), antiosteoporotic medications (-), teriparatide (MESH:D019379), atorvastatin (MESH:D000069059), furosemide (MESH:D005665), glargine insulin (MESH:D000069036), hydrocortisone (MESH:D006854), phenytoin (MESH:D010672), calcium carbonate (MESH:D002119), spironolactone (MESH:D013148), dabigatran (MESH:D000069604), aspirin (MESH:D001241), pantoprazole (MESH:D000077402), warfarin (MESH:D014859), Vitamin D (MESH:D014807), copper (MESH:D003300), zoledronic (MESH:D000077211)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Bos taurus (bovine, species) [taxon 9913], Felis catus (cat, species) [taxon 9685], Homo sapiens (human, species) [taxon 9606], Sus scrofa (pig, species) [taxon 9823]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC10824280/full.md

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC10824280/full.md

## References

99 references — full list in the complete paper: https://tomesphere.com/paper/PMC10824280/full.md

---
Source: https://tomesphere.com/paper/PMC10824280