# Front Cover

## TL;DR

This paper explores how a deficiency in SynCAM1 in certain brain cells contributes to cognitive issues in newborns exposed to sevoflurane.

## Contribution

It identifies SynCAM1's role in cognitive impairment linked to anesthetic exposure in neonates.

## Key findings

- SynCAM1 deficiency in parvalbumin interneurons is linked to cognitive impairment.
- Sevoflurane exposure exacerbates this issue in neonatal hippocampus.
- The study highlights a potential target for mitigating anesthetic-related cognitive effects.

## Abstract

The cover image is based on the Original Article SynCAM1 deficiency in the hippocampal parvalbumin interneurons contributes to sevoflurane‐induced cognitive impairment in neonatal by Ming‐ming Zhao et al., https://doi.org/10.1111/cns.14554.