# The two therapeutic strategies of surgical intervention and medical management in a patient with enhanced-fibrinolytic type of disseminated intravascular coagulation after aortic replacement for Stanford type A aortic dissection with chronic heart and renal failure

**Authors:** Hiroki Okamoto, Tomoya Ozawa, Tomoaki Suzuki, Yoshihisa Nakagawa

PMC · DOI: 10.1186/s12872-024-03750-0 · BMC Cardiovascular Disorders · 2024-01-29

## TL;DR

This case study explores two treatment approaches for a rare coagulation disorder in an elderly patient with complex medical history.

## Contribution

Presents a novel case of managing enhanced-fibrinolytic DIC through tailored surgical and medical strategies in a high-risk patient.

## Key findings

- Surgical intervention temporarily controlled hemorrhage in a patient with enhanced-fibrinolytic DIC.
- Combination of anticoagulant and antifibrinolytic agents successfully managed recurrent DIC symptoms.
- Tailored therapy based on patient comorbidities is crucial for managing complex DIC cases.

## Abstract

Management of the enhanced-fibrinolytic type of disseminated intravascular coagulation (DIC) caused by aortic disorders is the two strategies of surgical intervention and medical treatment based on the patient’s age and comorbidities.

An 81-year-old woman with a history of two previous aortic surgeries and chronic heart and renal failure was admitted for uncontrollable subcutaneous hemorrhage. The hemorrhage was caused by the enhanced-fibrinolytic type of disseminated intravascular coagulation (DIC) caused by periprosthetic graft hematoma after aortic replacement for Stanford type A aortic dissection. Open thoracic hemostasis temporarily controlled the subcutaneous hemorrhage, but she was readmitted for the recurrence seven months after discharge. On the second admission, the combination of anticoagulant and antifibrinolytic agents was successful.

Management of the enhanced-fibrinolytic type of DIC caused by aortic disorders is important of a successful combination of surgical and medical therapy tailored the patient’s condition.

## Linked entities

- **Diseases:** disseminated intravascular coagulation (MONDO:0001243), chronic renal failure (MONDO:0024327)

## Full-text entities

- **Genes:** OTOR (otoraplin) [NCBI Gene 56914] {aka FDP, MIAL1}, ANXA2 (annexin A2) [NCBI Gene 302] {aka ANX2, ANX2L4, CAL1H, HEL-S-270, LIP2, LPC2}, THBD (thrombomodulin) [NCBI Gene 7056] {aka AHUS6, BDCA-3, BDCA3, CD141, THPH12, THRM}, PLG (plasminogen) [NCBI Gene 5340] {aka HAE4}, FGB (fibrinogen beta chain) [NCBI Gene 2244] {aka HEL-S-78p}, SERPINC1 (serpin family C member 1) [NCBI Gene 462] {aka AT3, AT3D, ATIII, ATIII-R2, ATIII-T1, ATIII-T2}, TAT (tyrosine aminotransferase) [NCBI Gene 6898], SERPINE1 (serpin family E member 1) [NCBI Gene 5054] {aka PAI, PAI-1, PAI1, PLANH1}
- **Diseases:** hematoma (MESH:D006406), bleeding tendency (MESH:C536965), malignant tumor (MESH:D009369), aortic disorders (MESH:D000082862), Stanford type A aortic dissection (MESH:D000784), APL (MESH:D015473), left ventricular dysfunction (MESH:D018487), CRT-D (MESH:D006331), renal dysfunction (MESH:D007674), vascular disorders (MESH:D002561), coagulant disorder (MESH:D001778), trauma (MESH:D014947), thromboembolic complications (MESH:D013923), AF (MESH:D001281), DIC (MESH:D004211), Stanford type A (MESH:D006969), chronic kidney disease (MESH:D051436), dilated cardiomyopathy (MESH:D002311), hyperkalemia (MESH:D006947), heart and renal failure (MESH:D051437), left bundle branch block (MESH:D002037), dementia (MESH:D003704), heart failure (MESH:D006333), thrombus (MESH:D013927), multiple organ failure (MESH:D009102), liver failure (MESH:D017093), bleeding (MESH:D006470), microvascular thrombosis (MESH:D017566), infection (MESH:D007239), pseudoaneurysm (MESH:D017541)
- **Chemicals:** CRT-D (-), -D (MESH:D003903), Lead (MESH:D007854), nafamostat mesilate (MESH:C032855), Warfarin (MESH:D014859), camostat mesilate (MESH:C034532), heparin (MESH:D006493), PC (MESH:C053518), gabexate mesilate (MESH:D016670), tranexamic acid (MESH:D014148)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

16 references — full list in the complete paper: https://tomesphere.com/paper/PMC10823723/full.md

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Source: https://tomesphere.com/paper/PMC10823723