# Trachoma: an underdiagnosed disease revealed by a survey carried out at Jaú, São Paulo

**Authors:** Luisa Fioravanti Schaal, Roberta Lilian Fernandes de Sousa Meneghim, Lucieni Cristina Barbarini Ferraz, Carlos Roberto Padovani, Cassiano Victoria, Silvana Artioli Schellini

PMC · DOI: 10.1186/s12886-024-03302-2 · BMC Ophthalmology · 2024-01-29

## TL;DR

This study reveals the presence of inflammatory trachoma in children in Jaú, Brazil, highlighting areas with low socioeconomic conditions as hotspots.

## Contribution

The study identifies active trachoma cases in a region where the disease was previously thought absent, emphasizing the need for targeted health interventions.

## Key findings

- An adjusted prevalence rate of 2.65% of active trachoma was found in children aged 1-9 years.
- Higher prevalence (3.01%) was observed in children aged 6-9 years compared to younger children.
- Clusters of cases were identified in neighborhoods with lower socioeconomic conditions.

## Abstract

Trachoma is a notifiable disease in the state of São Paulo– Brazil. However, in Jaú, a municipality located in this state, in the last 10 years there are no records of cases. This study purpose is to assess if there are cases of inflammatory trachoma in schoolchildren aged 1 to 9 years in the municipality of Jaú as well if it is possible to detect clusters areas of the disease to establish elimination programs.

An epidemiological study was performed in 2018, involving a stratified random sample of schoolchildren aged 1- to 9-year-old, from public day care centers and elementary schools in the municipality of Jaú. A trachoma screening following the criteria of the World Health Organization (WHO) and the distribution of cases was assessed using geoprocessing.

Four thousand-six hundred-nineteen children from 44 elementary schools were examined, and 126 children with active trachoma were detected, with an adjusted prevalence rate of 2.65%. The prevalence was higher (3.01%) in children aged 6- to 9-year-old compared to children aged 1-to 5-year-old (2.42%). There were clusters with a higher concentration of positive cases of the disease in three schools located in the neighborhoods with lower socioeconomic conditions.

Inflammatory trachoma still present in children aged 1- to 9-year-old in the city of Jaú. The positive cases were located mainly in areas with low socioeconomic conditions. Health promotion with active search and periodical treatment must be planned to fight this important blinding cause, that persists in our municipality.

## Linked entities

- **Diseases:** trachoma (MONDO:0001249)

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** Inflammatory trachoma (MESH:D014141), HDI (MESH:D002658), infection (MESH:D007239), blindness (MESH:D001766)
- **Chemicals:** Azithromycin (MESH:D017963)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

29 references — full list in the complete paper: https://tomesphere.com/paper/PMC10823718/full.md

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Source: https://tomesphere.com/paper/PMC10823718