# Fission yeast spindle dynamics and chromosome segregation fidelity show distinct thermosensitivity

## TL;DR

The study shows that spindle dynamics and chromosome segregation in fission yeast have different optimal temperatures, suggesting a trade-off between accuracy and speed during cell division.

## Contribution

The novel finding is that spindle dynamics and segregation fidelity in fission yeast have distinct thermosensitivity profiles.

## Key findings

- Spindle dynamics peak around 35°C, while chromosome segregation defects are minimized at 25°C.
- Mitotic errors may be tolerated at higher temperatures to accelerate cell cycle progression.

## Abstract

Cellular processes rely on proteins with temperature-dependent stability and activity. While thermosensitivity in biological networks is well-explored, the effect of temperature on complex mechanochemical assemblies, like the spindle, is rarely studied. We examined fission yeast spindle dynamics and chromosome segregation from 15⁰C to 40⁰C. Our findings reveal that these parameters follow U-shaped temperature-dependent curves but reach their minima at different temperatures. Specifically, spindle dynamics peak around 35⁰C, whereas chromosome segregation defects are minimized at 25⁰C. This suggests a scenario in which mitotic errors are tolerated to expedite rapid cell cycle progression.