# Implementation of Multimodal Stimulation and Physical Therapy in Improving the Level of Consciousness and Recovery in Acute Disseminated Encephalomyelitis

**Authors:** Harsh R Nathani, Nishigandha P Deodhe, Ruchika J Zade, Grisha R Ratnani

PMC · DOI: 10.7759/cureus.51217 · Cureus · 2023-12-28

## TL;DR

This case report shows how combining sensory stimulation and physical therapy helped a woman recover from a severe brain condition called ADEM.

## Contribution

The study demonstrates the effectiveness of a combined therapeutic approach in ADEM rehabilitation.

## Key findings

- The patient showed improved consciousness levels using the Glasgow Coma Scale and related tools.
- Functional and neurological recovery was observed with multimodal therapy.
- Family involvement and collaborative care positively impacted recovery outcomes.

## Abstract

This case report aims to explore the use of multimodal sensory stimulation and physical therapy in rehabilitating a 30-year-old female patient with severe acute disseminated encephalomyelitis (ADEM). ADEM, characterized by autoimmune demyelination in the central nervous system, presents challenges in clinical management, particularly in cases with severe motor deficits and coordination issues. The patient's progress was measured using the Glasgow Coma Scale (GCS), Extended Glasgow Outcome Scale (GOS-E), and Coma Recovery Scale-Revised (CRS-R). The patient showed significant improvement in consciousness levels, functional status, and cognitive and neurological function. The study concludes that a collaborative approach involving both therapeutic modalities and active family participation contributed positively to the patient's recovery.

## Linked entities

- **Diseases:** acute disseminated encephalomyelitis (MONDO:0019383), ADEM (MONDO:0019383)

## Full-text entities

- **Diseases:** spasticity (MESH:D009128), hypertension (MESH:D006973), loss of consciousness (MESH:D014474), confusion (MESH:D003221), sensory impairments (MESH:D012678), diabetes (MESH:D003920), metabolic encephalopathy (MESH:D001928), head injury (MESH:D006259), demyelinating disorder (MESH:D003711), pulmonary infections (MESH:D012141), rabies (MESH:D011818), Coma (MESH:D003128), respiratory acidosis (MESH:D000142), tetraplegia (MESH:D011782), muscle contractions (MESH:C536214), vomiting (MESH:D014839), autoimmune demyelination in the (MESH:D020278), status epilepticus (MESH:D013226), cortical blindness (MESH:D019575), system (MESH:D015619), motor deficits (MESH:D009461), coordination difficulties (MESH:D001259), weakness (MESH:D018908), brain injuries (MESH:D001930), system involvement (MESH:D018860), Encephalomyelitis (MESH:D004679), viral infections (MESH:D014777), Edema (MESH:D004487), optic neuritis (MESH:D009902), decreased appetite (MESH:D001068), polyradiculoneuropathy (MESH:D011129), prolonged focal motor seizures (MESH:D012640), myalgias (MESH:D063806), nausea, (MESH:D009325), peripheral (MESH:D010523), autoimmune condition (MESH:D001327), neuroparalytic accidents (MESH:D000081084), rubella virus infections (MESH:D012409), encephalopathy (MESH:D001927), muscle atrophy (MESH:D009133), headache (MESH:D006261), varicella-zoster (MESH:D020804), meningism (MESH:D008580), range of motion (MESH:D009041), fever (MESH:D005334), lesions affecting the visual cortex (MESH:D014786), ADEM (MESH:D004673), severe (MESH:D045169), inflammatory (MESH:D007249), bladder dysfunctions (MESH:D001745)
- **Chemicals:** amantadine (MESH:D000547), oxygen (MESH:D010100), Pan (MESH:C041728), Levipil (-), HCO3 (MESH:D001639), calcium (MESH:D002118), phosphorus (MESH:D010758), lipid (MESH:D008055)
- **Species:** Leptospira (genus) [taxon 171], Borrelia (Relapsing Fever Borrelia, genus) [taxon 138], Homo sapiens (human, species) [taxon 9606], Variola virus (smallpox virus, no rank) [taxon 10255], Measles morbillivirus (no rank) [taxon 11234], Citrus x limon (lemon, species) [taxon 2708], Mycoplasma (genus) [taxon 2093]

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC10823210/full.md

## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC10823210/full.md

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Source: https://tomesphere.com/paper/PMC10823210