# Additional Cover

## TL;DR

This paper explores how APOE genotype, Tau levels, and insula network connectivity relate to cognition in Alzheimer's disease.

## Contribution

It identifies the moderating and mediating roles of insula network connectivity in Alzheimer's disease progression.

## Key findings

- APOE genotype influences cognitive outcomes through CSF Tau levels.
- The insula network connectivity mediates the relationship between Tau and cognition.
- Network connectivity moderates the effect of APOE genotype on cognitive decline.

## Abstract

The cover image is based on the Original Article The relationship between APOE genotype, CSF Tau and cognition across the Alzheimer’s disease spectrum, moderation and mediation role of insula network connectivity by Yao Zhu et al., https://doi.org/10.1111/cns.14401.