# Prolonged hiccups induced by renal infarction: a case report

**Authors:** Akira Kato, Nobuhiro Sato, Yasuo Hirose, Yuji Nomoto, Seiga Ozaki, Saori Yamaga, Masahiro Yabe

PMC · DOI: 10.1186/s13256-024-04347-z · Journal of Medical Case Reports · 2024-01-28

## TL;DR

A patient with prolonged hiccups was found to have a kidney infarction, suggesting a link between kidney issues and persistent hiccups.

## Contribution

This case report highlights a novel association between renal infarction and prolonged hiccups.

## Key findings

- Prolonged hiccups in a patient were linked to a diagnosis of right renal infarction.
- Computed tomography images supported the hypothesis that kidney inflammation stimulated the diaphragm, causing hiccups.

## Abstract

Hiccups are common symptoms that last for less than 48 hours. However, we encountered a case of renal infarction in a patient with prolonged hiccup. The relationship between hiccups and renal infarction is important in differentiating patients with prolonged hiccups.

An 87-year-old Japanese man with atrial fibrillation and receiving antithrombotic therapy presented to the emergency department with prolonged hiccups. The patient discontinued antithrombotic therapy for atrial fibrillation due to subcortical bleeding, after which he experienced right back pain. He was diagnosed with right renal infarction based on computed tomography images, and the antithrombotic therapy was continued. The patient’s hiccups ceased, and he was discharged on hospital day 11.

Hiccups can be induced by various clinical conditions. It is hypothesized that the inflammation of the right kidney infarction stimulated the diaphragm and induced prolonged hiccups in this patient; this theory is supported by the computed tomography images. This case report shows that internal organ diseases irritating the diaphragm can cause hiccups, and renal disease should be considered in patients with prolonged hiccups.

## Linked entities

- **Diseases:** atrial fibrillation (MONDO:0004981)

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, SPINK5 (serine peptidase inhibitor Kazal type 5) [NCBI Gene 11005] {aka LEKTI, LETKI, NETS, NS, VAKTI}
- **Diseases:** back pain (MESH:D001416), Intestinal and renal diseases (MESH:D007410), inflammation (MESH:D007249), hydronephrosis (MESH:D006869), flank pain (MESH:D021501), diaphragmatic irritation (MESH:D006548), abdominal or flank pain (MESH:D015746), renal cell carcinoma (MESH:D002292), proteinuria (MESH:D011507), costovertebral angle tenderness (MESH:D063806), emergency department (MESH:D004630), amyloid angiopathy (MESH:C538248), urinary tract infection (MESH:D014552), diseases (MESH:D004194), nausea (MESH:D009325), central nervous system diseases (MESH:D002493), thrombotic (MESH:D013927), bleeding (MESH:D006470), acute renal infarction (MESH:D056989), Right back pain (MESH:D010146), vagus nerve (MESH:D020421), acute tubular injury (MESH:D001930), diaphragmatic cramping (MESH:D009120), renal abscess (MESH:D000038), diseases of internal organs (MESH:D002340), metabolic diseases (MESH:D008659), kidney (MESH:D007674), hematuria (MESH:D006417), vomiting (MESH:D014839), carotid artery stenosis (MESH:D016893), kidney infarction (MESH:D007680), infarction (MESH:D007238), thromboembolism (MESH:D013923), Upper (MESH:D012141), Hiccups (MESH:D006606), atrial fibrillation (MESH:D001281), liver abscesses (MESH:D008100), abnormalities (MESH:D000014)
- **Chemicals:** creatinine (MESH:D003404), ceftriaxone (MESH:D002443), apixaban (MESH:C522181), antithrombotic (-), aspirin (MESH:D001241), oxygen (MESH:D010100)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC10822175/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC10822175/full.md

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Source: https://tomesphere.com/paper/PMC10822175