# Hashimoto’s thyroiditis presenting with cardiac tamponade: a case report

**Authors:** Muhammadnur Rachim Enoch, Muhammad Irfan, Rachmad Budianto, Achmad Hardin

PMC · DOI: 10.11604/pamj.2023.46.62.41687 · The Pan African Medical Journal · 2023-10-18

## TL;DR

A woman with Hashimoto's thyroiditis presented with cardiac tamponade, highlighting the rare connection between hypothyroidism and heart complications.

## Contribution

This case report highlights cardiac tamponade as an unusual initial sign of Hashimoto's thyroiditis.

## Key findings

- A 36-year-old female with acute respiratory distress was found to have cardiac tamponade due to Hashimoto's thyroiditis.
- Hormone replacement therapy improved hypothyroidism, but chronic pericardial effusion persisted.
- Clinicians should consider hypothyroidism as a cause of cardiac tamponade, especially without tachycardia.

## Abstract

Cardiac tamponade as the initial manifestation of Hashimoto's thyroiditis is an exceedingly uncommon occurrence. We present the case of a 36-year-old female who was admitted due to acute respiratory distress. A cardiac ultrasound revealed a severe pericardial effusion with tamponade signs. Subsequently, percutaneous pericardiocentesis was performed, resulting in a swift clinical improvement. Laboratory examinations confirmed severe hypothyroidism associated with Hashimoto's disease. Despite undergoing hormone replacement therapy, histological analysis of the pericardium revealed a chronic inflammation process. A follow-up cardiac ultrasound conducted six months later indicated the presence of a well-tolerated chronic pericardial effusion. In conclusion, clinicians should consider hypothyroidism as a potential cause when cardiac tamponade is observed, particularly in the absence of tachycardia. The prognosis is generally favorable with hormone replacement therapy, but regular ultrasound monitoring should be maintained until the patient achieves a euthyroid state.

## Linked entities

- **Diseases:** Hashimoto's thyroiditis (MONDO:0007699), hypothyroidism (MONDO:0005420), cardiac tamponade (MONDO:0001297)

## Full-text entities

- **Genes:** TSHR (thyroid stimulating hormone receptor) [NCBI Gene 7253] {aka CHNG1, LGR3, hTSHR-I}, TPO (thyroid peroxidase) [NCBI Gene 7173] {aka MSA, TDH2A, TPX}
- **Diseases:** cancer (MESH:D009369), Hashimoto's disease (MESH:D050031), sinus bradycardia (MESH:D012804), edema (MESH:D004487), uremia (MESH:D014511), Hypothyroidism (MESH:D007037), dyspnea (MESH:D004417), diastolic hypertension (MESH:C563897), acute respiratory distress (MESH:D012128), goiter (MESH:D006042), Cardiac tamponade (MESH:D002305), Beck's triad (MESH:D007619), inflammation (MESH:D007249), ventricular arrhythmias (MESH:D001145), pulse pressure (MESH:D003668), Pericardial effusion (MESH:D010490), autoimmune disorder (MESH:D001327), effusion (MESH:D000080324), chamber collapse (MESH:D001261), heart failure (MESH:D006333), dyslipidemia (MESH:D050171), tachycardia (MESH:D013610), hypotension (MESH:D007022), lupus (MESH:D008180), jugular vein distention (MESH:D005925), trauma (MESH:D014947), cardiomegaly (MESH:D006332), tuberculosis (MESH:D014376), bradycardia (MESH:D001919), QTc intervals (OMIM:610141), pericarditis (MESH:D010493), RBBB (MESH:D002037), sinus tachycardia (MESH:D013616), autoimmune thyroid disorder (MESH:D013967), right ventricular (RV) collapse (MESH:D018497)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC10822107/full.md

## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC10822107/full.md

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Source: https://tomesphere.com/paper/PMC10822107