# Renal Metastatic Melanoma Presenting With Solitary Mass

**Authors:** Tuğçem Bıçak, Selver Ozekinci, Yekta Bıçak, Mansur Dağgülli

PMC · DOI: 10.7759/cureus.51253 · Cureus · 2023-12-28

## TL;DR

This paper discusses a rare case of melanoma spreading to the kidney and highlights the importance of considering metastasis in unusual locations.

## Contribution

The novelty lies in presenting a rare clinical case of melanoma metastasis to the kidney and emphasizing diagnostic considerations.

## Key findings

- Melanoma metastasis to the kidney is rare and can mimic other renal tumors.
- A thorough patient history is essential for accurate diagnosis in such cases.

## Abstract

The kidney is a rare site of metastatic implantation. Metastases to the kidney most commonly originate from carcinomas in the lungs, breasts, and colon. Melanoma metastasis to the kidney is rare. We present an unusual case of melanoma metastasis to the kidney arising in a 76-year-old male who was diagnosed with melanoma two years ago. We emphasize the importance of thorough patient anamnesis when diagnosing renal cell carcinoma or urothelial carcinoma is challenging. In cases where patients with a history of melanoma present with new masses or lesions, even in atypical areas, considering melanoma metastasis in the differential diagnosis is crucial.

## Linked entities

- **Diseases:** melanoma (MONDO:0005105), renal cell carcinoma (MONDO:0005086), urothelial carcinoma (MONDO:0040679)

## Full-text entities

- **Genes:** SMN1 (survival of motor neuron 1, telomeric) [NCBI Gene 6606] {aka BCD541, GEMIN1, SMA, SMA1, SMA2, SMA3}, S100A1 (S100 calcium binding protein A1) [NCBI Gene 6271] {aka S100, S100-alpha, S100A}, TP63 (tumor protein p63) [NCBI Gene 8626] {aka AIS, B(p51A), B(p51B), EEC3, KET, LMS}, SLC4A3 (solute carrier family 4 member 3) [NCBI Gene 6508] {aka AE3, CAE3/BAE3, SLC2C, SQT7}, SLC4A1 (solute carrier family 4 member 1 (Diego blood group)) [NCBI Gene 6521] {aka AE1, BND3, CD233, CHC, DI, EMPB3}, IL2 (interleukin 2) [NCBI Gene 3558] {aka IL-2, TCGF, lymphokine}, GATA3 (GATA binding protein 3) [NCBI Gene 2625] {aka HDR, HDRS}, SOX10 (SRY-box transcription factor 10) [NCBI Gene 6663] {aka DOM, PCWH, SOX-10, WS2E, WS4, WS4C}, TFE3 (transcription factor binding to IGHM enhancer 3) [NCBI Gene 7030] {aka MRXSPF, RCCP2, RCCX1, TFEA, bHLHe33}, KRT7 (keratin 7) [NCBI Gene 3855] {aka CK7, K2C7, K7, SCL}, PRAME (PRAME nuclear receptor transcriptional regulator) [NCBI Gene 23532] {aka CT130, MAPE, OIP-4, OIP4}, PAX8 (paired box 8) [NCBI Gene 7849] {aka PAX-8}, MLANA (melan-A) [NCBI Gene 2315] {aka MART-1, MART1}
- **Diseases:** Renal Metastatic Melanoma (MESH:D008545), lungs (MESH:D008171), nocturia (MESH:D053158), angiosarcoma (MESH:D006394), hematuria (MESH:D006417), Melanomas of the kidney (MESH:D007674), lymph nodes (MESH:D000072717), died (MESH:D003643), flank pain (MESH:D021501), sarcomas (MESH:D012509), renal mass (MESH:C536030), dysuria (MESH:D053159), melanin-pigmented renal cell carcinoma (MESH:D002292), leiomyosarcoma (MESH:D007890), angiomyolipoma (MESH:D018207), Melanoma metastasis (MESH:D009362), urothelial carcinoma (MESH:D014523), Malignancies (MESH:D009369), primary renal neoplasms (MESH:D007680), CCS (MESH:D018227), PEComa (MESH:D054973)
- **Chemicals:** Formalin (MESH:D005557), melanin pigment (-), melanin (MESH:D008543), fotemustine (MESH:C054368), paraffin (MESH:D010232), dacarbazine (MESH:D003606)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606]
- **Cell lines:** H&amp;E — Homo sapiens (Human), Transformed cell line (CVCL_ZD53)

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC10822033/full.md

## References

6 references — full list in the complete paper: https://tomesphere.com/paper/PMC10822033/full.md

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Source: https://tomesphere.com/paper/PMC10822033