# Comparative Sensing and Judgment Control System for Temperature Maintenance for Optimal Treatment in Hyperthermic Intraperitoneal Chemotherapy Surgery

## TL;DR

This paper introduces a system to maintain optimal temperature during chemotherapy by using feedback to adjust heat input automatically.

## Contribution

A novel look-up table module design for stable temperature control in hyperthermic chemotherapy is proposed.

## Key findings

- The system uses feedback to adjust heat input when drug temperatures fall outside the 41–43 °C range.
- The proposed system ensures rapid, accurate, and safe treatment by maintaining the optimal temperature range.
- The LUT module sends command signals to a heat exchanger to regulate temperature dynamically.

## Abstract

For tumors wherein cancer cells remain in the tissue after colorectal cancer surgery, a hyperthermic anticancer agent is injected into the abdominal cavity to necrotize the remaining cancer cells with heat using a hyperthermic intraperitoneal chemotherapy system. However, during circulation, the processing temperature is out of range and the processing result is deteriorated. This paper proposes a look-up table (LUT) module design method that can stably maintain the processing temperature range during circulation via feedback. If the temperature decreases or increases, the LUT transmits a command signal to the heat exchanger to reduce or increase heat input, thereby maintaining the treatment temperature range. The command signal for increasing and decreasing heat input is Tp and Ta, respectively. The command signal for the treatment temperature range is Ts. If drug temperatures below 41 and above 43 °C are input to the LUT, it sends a Tp or Ta signal to the heat exchanger to increase or decrease the input heat, respectively. If the drug’s temperature is 41–43 °C, the LUT generates a Ts signal and proceeds with the treatment. The proposed system can automatically control drug temperature using temperature feedback to ensure rapid, accurate, and safe treatment.