Mortality Trend of Severe COVID-19 in Under-Vaccinated Population Admitted to ICU in French Amazonia
Séverine Matheus, Stéphanie Houcke, Guy Roger Lontsi Ngoulla, Nicolas Higel, Abesetou Ba, Fabrice Cook, Cyrille Gourjault, Flaubert Nkontcho, Magalie Demar, Mathieu Nacher, Félix Djossou, Didier Hommel, Dabor Résiere, Jean Marc Pujo, Hatem Kallel

TL;DR
This study found that severe COVID-19 mortality in French Guiana increased during the Delta variant wave due to low vaccination rates and the variant's higher virulence.
Contribution
The study provides insights into how under-vaccination and variant virulence impact ICU mortality in a specific geographic region.
Findings
Hospital mortality increased from 30.9% during the original variant to 47.1% during the Delta variant wave.
Age, frailty, immunosuppression, and mechanical ventilation use were independent factors associated with higher mortality.
The mortality prediction model had a sensitivity of 72% and a specificity of 80.4%.
Abstract
(1) Background: Until December 2021, French Guiana (FG), located in South America, faced four consecutive COVID-19 epidemic waves. This study sought to analyze the mortality trend of severe COVID-19 patients admitted to the referral ICU of FG. (2) Methods: We conducted a prospective, observational, and non-interventional study in ICU at Cayenne Hospital. We included 383 patients older than 18 admitted with SARS-CoV-2-related pneumonia hospitalized from May 2020 to December 2021. The study covers three periods. Period 1 (Waves 1 and 2, original variant), period 2 (Wave 3, Gamma variant), and period 3 (Wave 4, Delta variant). (3) Results: The median age was 63 years (52–70). Frailty was diagnosed in 36 patients over 70 (32.4%). Only 4.8% of patients were vaccinated. The median ICU LOS was 10 days (6–19). Hospital mortality was 37.3%. It was 30.9% in period 1, 36.6% in period 2 (p = 0.329…
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Taxonomy
TopicsCOVID-19 Clinical Research Studies · COVID-19 and healthcare impacts · Immune responses and vaccinations
