# Nutritional Supplements for Skin Health—A Review of What Should Be Chosen and Why

**Authors:** Jacek Januszewski, Alicja Forma, Julita Zembala, Michał Flieger, Magdalena Tyczyńska, James Curtis Dring, Iga Dudek, Kamila Świątek, Jacek Baj

PMC · DOI: 10.3390/medicina60010068 · 2023-12-29

## TL;DR

This paper reviews 14 nutritional supplements that may help improve skin health and protect against UV damage.

## Contribution

The paper provides a comprehensive review of 14 supplements and their potential benefits for skin conditions and UV protection.

## Key findings

- Supplements like vitamin A, C, D, and E showed potential benefits for skin health and inflammation.
- Some compounds like curcumin and Omega-3 may help protect against UV radiation and skin diseases.
- Further research is needed to determine optimal doses for these supplements.

## Abstract

Supplementation of micronutrients is considered to be crucial in the reinforcement of the skin’s barrier. In this paper, 14 nutritional compounds commonly used in food or pharmaceutic industries were analyzed in terms of influencing skin conditions. The major objective of this paper was to provide a narrative review of the available literature regarding several chosen compounds that are currently widely recommended as supplements that aim to maintain proper and healthy skin conditions. We conducted a review of the literature from PubMed, Scopus, and Web of Science until September 2023 without any other restrictions regarding the year of the publication. Ultimately, we reviewed 238 articles, including them in this review. Each of the reviewed compounds, including vitamin A, vitamin C, vitamin D, vitamin E, curcumin, chlorella, Omega-3, biotin,Ppolypodium leucotomos, Simmondsia chinesis, gamma oryzanol, olive leaf extract, spirulina, and astaxanthin, was observed to present some possible effects with promising benefits for a skin condition, i.e., photoprotective radiation. Adding them to the diet or daily routine might have a positive influence on some skin inflammatory diseases such as atopic dermatitis or psoriasis. Further, UV radiation protection facilitated by some supplements and their impact on human cells might be helpful during chemotherapy or in preventing melanoma development. Further research is needed because of the lack of clear consensus regarding the doses of the described compounds that could provide desirable effects on the skin.

## Linked entities

- **Chemicals:** vitamin A (PubChem CID 445354), vitamin C (PubChem CID 54670067), vitamin E (PubChem CID 14985), curcumin (PubChem CID 969516), Omega-3 (PubChem CID 1548943), biotin (PubChem CID 171548), gamma oryzanol (PubChem CID 5282164), astaxanthin (PubChem CID 5281224)
- **Diseases:** atopic dermatitis (MONDO:0004980), psoriasis (MONDO:0005083), melanoma (MONDO:0005105)

## Full-text entities

- **Genes:** CASP3 (caspase 3) [NCBI Gene 836] {aka CPP32, CPP32B, SCA-1}, Egf (epidermal growth factor) [NCBI Gene 13645], IFNG (interferon gamma) [NCBI Gene 3458] {aka IFG, IFI, IMD69}, Retn (resistin) [NCBI Gene 57264] {aka ADSF, Fizz3, Rstn, Xcp4}, CXCL8 (C-X-C motif chemokine ligand 8) [NCBI Gene 3576] {aka GCP-1, GCP1, IL8, LECT, LUCT, LYNAP}, CAMP (cathelicidin antimicrobial peptide) [NCBI Gene 820] {aka CAP-18, CAP18, CRAMP, FALL-39, FALL39, HSD26}, IL1B (interleukin 1 beta) [NCBI Gene 3553] {aka IL-1, IL1-BETA, IL1F2, IL1beta}, CYP11A1 (cytochrome P450 family 11 subfamily A member 1) [NCBI Gene 1583] {aka CYP11A, CYPXIA1, P450SCC}, CCN1 (cellular communication network factor 1) [NCBI Gene 3491] {aka CYR61, GIG1, IBP-10, IGFBP-10, IGFBP10}, EGF (epidermal growth factor) [NCBI Gene 1950] {aka HOMG4, URG}, Nos2 (nitric oxide synthase 2, inducible) [NCBI Gene 18126] {aka MAC-NOS, NOS-II, Nos-2, Nos2a, i-NOS, iNOS}, BAX (BCL2 associated X, apoptosis regulator) [NCBI Gene 581] {aka BCL2L4}, FADD (Fas associated via death domain) [NCBI Gene 8772] {aka GIG3, IMD90, MORT1}, CYP4F3 (cytochrome P450 family 4 subfamily F member 3) [NCBI Gene 4051] {aka CPF3, CYP4F, CYPIVF3, LTB4H}, IL2 (interleukin 2) [NCBI Gene 3558] {aka IL-2, TCGF, lymphokine}, TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}, Tnf (tumor necrosis factor) [NCBI Gene 21926] {aka DIF, TNF-a, TNF-alpha, TNFSF2, TNFalpha, Tnfa}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, Acta2 (actin alpha 2, smooth muscle, aorta) [NCBI Gene 11475] {aka 0610041G09Rik, Actvs, SMAalpha, SMalphaA, a-SMA, alphaSMA}, SMG1 (SMG1 nonsense mediated mRNA decay associated PI3K related kinase) [NCBI Gene 23049] {aka 61E3.4, ATX, LIP}, IL10 (interleukin 10) [NCBI Gene 3586] {aka CSIF, GVHDS, IL-10, IL10A, TGIF}, VDR (vitamin D receptor) [NCBI Gene 7421] {aka NR1I1, PPP1R163}, BCO1 (beta-carotene oxygenase 1) [NCBI Gene 53630] {aka BCDO, BCDO1, BCMO, BCMO1, BCO}, CD4 (CD4 molecule) [NCBI Gene 920] {aka CD4mut, IMD79, Leu-3, OKT4D, T4}, CCL2 (C-C motif chemokine ligand 2) [NCBI Gene 6347] {aka GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1}, Retnla (resistin like alpha) [NCBI Gene 57262] {aka 1810019L16Rik, Fizz-1, Fizz1, HIMF, RELM-alpha, RELMa}, Trp53-ps (transformation related protein 53, pseudogene) [NCBI Gene 22060], IL1A (interleukin 1 alpha) [NCBI Gene 3552] {aka IL-1 alpha, IL-1A, IL1, IL1-ALPHA, IL1F1}, MMP2 (matrix metallopeptidase 2) [NCBI Gene 4313] {aka CLG4, CLG4A, MMP-2, MMP-II, MONA, TBE-1}, SOD1 (superoxide dismutase 1) [NCBI Gene 6647] {aka ALS, ALS1, HEL-S-44, IPOA, SOD, STAHP}, Hpgds (hematopoietic prostaglandin D synthase) [NCBI Gene 54486] {aka H-PGDS, Ptgds2}, PARP1 (poly(ADP-ribose) polymerase 1) [NCBI Gene 142] {aka ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1}, MMP1 (matrix metallopeptidase 1) [NCBI Gene 4312] {aka CLG}
- **Diseases:** brittle nail syndrome (MESH:D009260), depression (MESH:D003866), lung cancer (MESH:D008175), dryness and irritation of the skin (MESH:D014987), autoimmune and chronic inflammatory disorders (MESH:D019693), AD (MESH:D003876), cardiac diseases (MESH:D006331), Psoriasis (MESH:D011565), pruritus (MESH:D011537), facial redness (MESH:D005153), erythema (MESH:D004890), oral lichen planus (MESH:D017676), cancer (MESH:D009369), type III-VI (MESH:C536047), allergic (MESH:D004342), biotin deficiency (MESH:C531633), alopecia areata (MESH:D000506), burn (MESH:D002056), nuclear strictures (MESH:D003251), SLE (MESH:D008180), skeletal and cardiovascular disorders (MESH:D018376), acne (MESH:D000152), cytotoxicity (MESH:D064420), cardiovascular pathology (MESH:D002318), bacterial infection (MESH:D001424), breast cancer (MESH:D001943), hypertension (MESH:D006973), paraneoplastic syndromes (MESH:D010257), reproductive diseases (MESH:D060737), herpes (MESH:C536395), pemphigoid (MESH:D010391), inflammatory skin diseases (MESH:D012871), Muscle weight loss (MESH:D015431), mycosis fungoides (MESH:D009182), hypertriglyceridemia (MESH:D015228), vitamin A (MESH:D014802), wounds (MESH:D014947), Skin cancer (MESH:D012878), HIV-infected (MESH:D015658), dermatitis (MESH:D003872), hereditary enzyme deficiencies (MESH:D009386), respiratory illness (MESH:D012140), hepatitis (MESH:D056486), vitiligo (MESH:D014820), gastrointestinal symptoms (MESH:D012817), erythema multiforme (MESH:D004892), atherosclerotic plaque (MESH:D058226), cutaneous inflammatory illnesses (MESH:D018746), skin injury (MESH:D000069836), skin desquamation (MESH:D017490), inflammatory skin disorders (MESH:D012868), psoriatic (MESH:D015535), hair disorders (MESH:D006201), obesity (MESH:D009765), vitiligo vulgaris (MESH:D016112), alopecia (MESH:D000505), vitamin D deficiency (MESH:D014808), epidermolysis bullosa (MESH:D004820), Deficiencies (MESH:D007153), systemic disorders (MESH:D009422)
- **Chemicals:** ASX (MESH:C005948), PCL (MESH:C016240), superoxide (MESH:D013481), carotenoid (MESH:D002338), Beta-carotene (MESH:D019207), PGE2 (MESH:D015232), fat (MESH:D005223), water (MESH:D014867), melanin (MESH:D008543), ester (MESH:D004952), labrasol (MESH:C440220), AMPs (-), wax (MESH:D014885), Curcumin (MESH:D003474), tazarotene (MESH:C086827), PUFAs (MESH:D005231), oleic acid (MESH:D019301), polyphenols (MESH:D059808), Vitamin D (MESH:D014807), lumisterol (MESH:D004875), THC (MESH:C096277), Cyclobutane Pyrimidine Dimers (MESH:D011740), Curcuminoid (MESH:D036381), Vitamin A (MESH:D014801), zinc (MESH:D015032), iron (MESH:D007501), Omega-3 (MESH:D015525), glycosaminoglycan (MESH:D006025), alcohol (MESH:D000438), SFN (MESH:C016766), reactive nitrogen species (MESH:D026361), Vitamin E (MESH:D014810), fatty acid (MESH:D005227), Fluconazole (MESH:D015725), doxorubicin (MESH:D004317), alpha-tocopherol (MESH:D024502), ROS (MESH:D017382), folate (MESH:D005492), peroxides (MESH:D010545), lutein (MESH:D014975), flavonoids (MESH:D005419), Biotin (MESH:D001710), L-Ascorbic Acid (MESH:D001205), retinoic acid (MESH:D014212), melatonin (MESH:D008550), temozolomide (MESH:D000077204), free radicals (MESH:D005609), lipid (MESH:D008055), retinal (MESH:D012172), sugars (MESH:D000073893), Oleuropein (MESH:C002769), sulfhydryl (MESH:D013438), cholesterol (MESH:D002784), GO (MESH:C013172), xanthophyll (MESH:D024341), sucrose (MESH:D013395), Essential oils (MESH:D009822), minerals (MESH:D008903), selen (MESH:D012643), nanogel (MESH:C413692)
- **Species:** Brassica oleracea var. italica (asparagus broccoli, varietas) [taxon 36774], Chlorella virus (species) [taxon 10507], Bacteria Latreille et al. 1825 (Bacteria stick insect, genus) [taxon 629395], Human alphaherpesvirus 1 (Herpes simplex virus type 1, no rank) [taxon 10298], Brevibacterium linens (species) [taxon 1703], Homo sapiens (human, species) [taxon 9606], Human immunodeficiency virus 1 (no rank) [taxon 11676], Rattus norvegicus (brown rat, species) [taxon 10116], Curcuma longa (turmeric, species) [taxon 136217], Spirulina (suborder) [taxon 551299], Mus musculus (house mouse, species) [taxon 10090], Pseudomonas aeruginosa (species) [taxon 287], Brevibacterium epidermidis (species) [taxon 1698], Cavia porcellus (domestic guinea pig, species) [taxon 10141], Candida albicans (species) [taxon 5476], Staphylococcus aureus (species) [taxon 1280], Simmondsia chinensis (goatnut, species) [taxon 3999]
- **Mutations:** R24C, Q61K
- **Cell lines:** B16F10 — Mus musculus (Mouse), Mouse melanoma, Cancer cell line (CVCL_0159)

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC10820017/full.md

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Source: https://tomesphere.com/paper/PMC10820017