# Epithelial–Mesenchymal Transition (EMT) **Authors:** Guidalberto Manfioletti, Monica Fedele PMC · DOI: 10.3390/ijms241411386 · International Journal of Molecular Sciences · 2023-07-13 ## Full-text entities - **Genes:** KMT2D (lysine methyltransferase 2D) [NCBI Gene 8085] {aka AAD10, ALR, BCAHH, CAGL114, KABUK1, KMS}, Crebbp (CREB binding lysine acetyltransferase) [NCBI Gene 54244] {aka CBP, RSTS, RTS}, Tgfb1 (transforming growth factor, beta 1) [NCBI Gene 59086] {aka Tgfb}, HDAC1 (histone deacetylase 1) [NCBI Gene 3065] {aka GON-10, HD1, KDAC1, RPD3, RPD3L1}, HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1) [NCBI Gene 3181] {aka HNRNPA2, HNRNPB1, HNRPA2, HNRPA2B1, HNRPB1, IBMPFD2}, Mtor (mechanistic target of rapamycin kinase) [NCBI Gene 56717] {aka 2610315D21Rik, FRAP, FRAP2, Frap1, RAFT1, RAPT1}, YTHDF1 (YTH N6-methyladenosine RNA binding protein F1) [NCBI Gene 54915] {aka C20orf21, DF1}, Nfkb1 (nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105) [NCBI Gene 18033] {aka NF-KB1, NF-kappaB, NF-kappaB1, p105, p50, p50/p105}, Trp53-ps (transformation related protein 53, pseudogene) [NCBI Gene 22060], Ctnnb1 (catenin beta 1) [NCBI Gene 84353] {aka Catnb}, Parp12 (poly (ADP-ribose) polymerase family, member 12) [NCBI Gene 243771] {aka 9930021O16, ARTD12, PARP-12, Zc3hdc1}, IGF2BP2 (insulin like growth factor 2 mRNA binding protein 2) [NCBI Gene 10644] {aka IMP-2, IMP2, VICKZ2}, MMP9 (matrix metallopeptidase 9) [NCBI Gene 4318] {aka CLG4B, GELB, MANDP2, MMP-9}, MIR100HG (mir-100-let-7a-2-mir-125b-1 cluster host gene) [NCBI Gene 399959] {aka AGD1, linc-NeD125, lncRNA-N2}, FOXM1 (forkhead box M1) [NCBI Gene 2305] {aka FKHL16, FOXM1A, FOXM1B, FOXM1C, HFH-11, HFH11}, TGFB1 (transforming growth factor beta 1) [NCBI Gene 7040] {aka CAEND1, CED, DPD1, IBDIMDE, LAP, TGF-beta1}, KMT2C (lysine methyltransferase 2C) [NCBI Gene 58508] {aka HALR, KLEFS2, MLL3}, Mrtfa (myocardin related transcription factor A) [NCBI Gene 315151] {aka BSAC, FLMKL1, MELODY, MKL1met, Mkl1, Mrtf-a}, SPARC (secreted protein acidic and cysteine rich) [NCBI Gene 6678] {aka BM-40, OI17, ON, ONT}, IGFBP2 (insulin like growth factor binding protein 2) [NCBI Gene 3485] {aka IBP2, IGF-BP53}, IL1B (interleukin 1 beta) [NCBI Gene 3553] {aka IL-1, IL1-BETA, IL1F2, IL1beta}, Smad3 (SMAD family member 3) [NCBI Gene 25631] {aka Madh3, Smad 3, mad3}, CDH2 (cadherin 2) [NCBI Gene 1000] {aka ACOGS, ADHD8, ARVD14, CD325, CDHN, CDw325}, Ptk2 (PTK2 protein tyrosine kinase 2) [NCBI Gene 14083] {aka FADK 1, FAK, FRNK, Fadk, p125FAK}, PRDM9 (PR/SET domain 9) [NCBI Gene 56979] {aka KMT8B, MEISETZ, MSBP3, PFM6, ZNF899}, LEP (leptin) [NCBI Gene 3952] {aka LEPD, OB, OBS}, SNAI1 (snail family transcriptional repressor 1) [NCBI Gene 6615] {aka SLUGH2, SNA, SNAH, SNAIL, SNAIL1, dJ710H13.1}, SNAI2 (snail family transcriptional repressor 2) [NCBI Gene 6591] {aka SLUG, SLUGH, SLUGH1, SNAIL2, WS2D}, ELANE (elastase, neutrophil expressed) [NCBI Gene 1991] {aka ELA2, GE, HLE, HNE, NE, PMN-E}, Parp1 (poly (ADP-ribose) polymerase family, member 1) [NCBI Gene 11545] {aka 5830444G22Rik, ARTD1, Adprp, Adprt1, PARP, PPOL}, Tff1 (trefoil factor 1) [NCBI Gene 21784] {aka Bcei, PS2}, TCF7L2 (transcription factor 7 like 2) [NCBI Gene 6934] {aka TCF-4, TCF4}, Akt1 (Akt serine/threonine kinase 1) [NCBI Gene 11651] {aka Akt, LTR-akt, PKB, PKB/Akt, PKBalpha, Rac} - **Diseases:** colon cancer (MESH:D015179), GBM (MESH:D005910), melanoma (MESH:D008545), inflammatory (MESH:D007249), gastric cancer (MESH:D013274), hypoxia (MESH:D000860), idiopathic pulmonary fibrosis (MESH:D054990), metastasis (MESH:D009362), thyroid carcinoma (MESH:D013964), glioblastoma (MESH:D005909), triple-negative breast cancer (MESH:D064726), injury to people or property (MESH:C000719191), cataracts (MESH:D002386), renal fibrosis (MESH:D005355), hypertensive kidney disease (MESH:D007674), NETs (MESH:C536657), extracellular (MESH:C535509), cancer (MESH:D009369), gastric injury (MESH:D013272), osteosarcoma (MESH:D012516), PCO (MESH:D057851), hepatocellular carcinoma (MESH:D006528), hypoxic (MESH:D002534), breast cancer (MESH:D001943), HNSCC (MESH:D000077195), hypertensive nephroangiosclerosis (MESH:D006973), ductal carcinoma in situ (MESH:D002285), lymph node metastases (MESH:D008207), breast (MESH:D061325) - **Chemicals:** lipids (MESH:D008055), m6A (MESH:C005955), amino-acid (MESH:D000596), cholesterol (MESH:D002784), PAR (MESH:C028398), Isoviolanthin (MESH:C000628639), Olaparib (MESH:C531550), chalcone (MESH:D002599), Bornyl cis-4-hydroxycinnamate (-), cetuximab (MESH:D000068818), chalcones (MESH:D047188), Sinomenine Hydrochloride (MESH:C009271), glucose (MESH:D005947), Poly-adenosine diphosphate (ADP)-ribose (MESH:D011064), N6-methyladenosine (MESH:C010223), chrysotile (MESH:D017632) - **Species:** Dendrobium officinale (species) [taxon 142615], Homo sapiens (human, species) [taxon 9606], Rattus norvegicus (brown rat, species) [taxon 10116] - **Cell lines:** NMuMG — Mus musculus (Mouse), Spontaneously immortalized cell line (CVCL_0075), AGS — Homo sapiens (Human), Gastric adenocarcinoma, Cancer cell line (CVCL_0139) ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC10379270/full.md ## References 31 references — full list in the complete paper: https://tomesphere.com/paper/PMC10379270/full.md --- Source: https://tomesphere.com/paper/PMC10379270