Autonomous metal-organic framework nanorobots for active mitochondria-targeted cancer therapy
Xiqi Peng, Songsong Tang, Daitian Tang, Dewang Zhou, Yangyang Li, Qiwei Chen, Fangchen Wan, Heather Lukas, Hong Han, Xueji Zhang, Wei Gao, Song Wu
TL;DR
Researchers developed autonomous nanorobots that deliver drugs directly to mitochondria in cancer cells, improving treatment effectiveness and reducing side effects.
Contribution
The nanorobots use a metal-organic framework to enable active, mitochondria-targeted drug delivery within tumor cells.
Findings
The nanorobots induce mitochondria-mediated apoptosis and dysregulation in cancer cells.
They show improved in vitro anticancer effects and suppression of cancer cell metastasis.
In vivo tests confirmed their efficacy in subcutaneous and orthotopic breast tumor models.
Abstract
Nanorobotic manipulation to access subcellular organelles remains unmet due to the challenge in achieving intracellular controlled propulsion. Intracellular organelles, such as mitochondria, are an emerging therapeutic target with selective targeting and curative efficacy. We report an autonomous nanorobot capable of active mitochondria-targeted drug delivery, prepared by facilely encapsulating mitochondriotropic doxorubicin-triphenylphosphonium (DOX-TPP) inside zeolitic imidazolate framework-67 (ZIF-67) nanoparticles. The catalytic ZIF-67 body can decompose bioavailable hydrogen peroxide overexpressed inside tumor cells to generate effective intracellular mitochondriotropic movement in the presence of TPP cation. This nanorobot-enhanced targeted drug delivery induces mitochondria-mediated apoptosis and mitochondrial dysregulation to improve the in vitro anticancer effect and…
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Taxonomy
TopicsMicro and Nano Robotics · Molecular Communication and Nanonetworks · Nanoplatforms for cancer theranostics