Open-source segmentation and biometry dataset using spectrally-multiplexed whole-eye optical coherence tomography

TL;DR

This paper introduces a spectrally-multiplexed whole-eye OCT system with an automated processing pipeline, providing accurate 3D ocular measurements and a large open-source dataset to advance eye imaging research.

Contribution

The authors develop a novel dual-wavelength WEOCT system with deep learning-based processing and release a large annotated dataset to support ocular biometry research.

Findings

Accurate simultaneous measurements of cornea topography and 3D pupil center.

Demonstrated system's effectiveness through user and phantom studies.

Published a large open-source dataset of processed ocular volumes.

Abstract

Whole-eye optical coherence tomography (WEOCT) has emerged as a transformative imaging modality capable of simultaneously capturing the anterior and posterior segments of the human eye. WEOCT enables comprehensive ocular biometry, which is critical for a wide range of clinical and research applications-from intraocular lens power calculation, myopia progression monitoring, and refractive surgery planning to the precise measurement of the visual and optical axes and the generation of personalized eye models for eye tracking in virtual, augmented and mixed reality(VR/AR/MR). However, existing WEOCT systems often face trade-offs between signal-to-noise ratio, imaging speed, and the ability to capture dynamic processes without motion artifacts. To address these limitations, we present a novel spectrally-multiplexed WEOCT system that utilizes two synchronized 200 kHz swept sources at 1310 nm and 1060 nm. Coupled with an automated end-to-end processing pipeline involving deep learning-based surface segmentation, 3D distortion correction, surface fitting and ray-tracing refraction correction, our system enables anatomically accurate 3D reconstruction of the segmented ocular layers. Through a 300+ participant user study and comprehensive phantom studies, we demonstrate that our system can provide simultaneous accurate measurements of cornea topography and 3D pupil center. While labeled retinal OCT data is abundantly available in open-source repositories, labeled B-scan or volumetric anterior segment data remains significantly limited. Consequently, research groups working in related domains must often acquire their own data using custom imaging systems. To help bridge this gap, we are releasing as open-source a comprehensive dataset comprising 6,621 processed volumes from 276 unique participants with corresponding segmentation and calibrated 3D anterior point clouds.