Bridging the Rural Healthcare Gap: A Cascaded Edge-Cloud Architecture for Automated Retinal Screening

TL;DR

This paper presents a two-tier edge-cloud system for diabetic retinopathy screening that reduces cloud data transmission by half while maintaining high diagnostic accuracy, suitable for rural healthcare settings.

Contribution

It introduces a cascaded architecture combining local lightweight models and cloud-based detailed grading to address rural healthcare infrastructure limitations.

Findings

Tier 1 achieves 98.99% sensitivity and 84.37% specificity.

The cascade reduces cloud calls by approximately 50%.

Maintains comparable accuracy to cloud-only models with reduced cloud usage.

Abstract

Diabetic Retinopathy (DR) is one of the leading causes of preventable blindness, yet rural regions often lack the specialists and infrastructure needed for early detection. Although cloud-based deep learning systems offer high accuracy, they face significant challenges in these settings due to high latency, limited bandwidth, and high data transmission costs. To address these challenges, we propose a two-tier edge-cloud cascade on the public APTOS 2019 Blindness Detection dataset. Tier 1 runs a lightweight MobileNetV3-small model on a local clinic device to perform a binary triage between Referable DR (Classes 2-4) and Non-referable DR (Classes 0-1). Tier 2 runs a RETFoundDINOv2 model in the cloud for ordinal severity grading, but only on the subset of images flagged as referable by Tier 1. On a stratified APTOS test split of 733 images, Tier 1 reaches 98.99% sensitivity and 84.37% specificity at a validation-tuned high-sensitivity threshold. The default cascade forwards 49.52% of test images to Tier 2, reducing cloud calls by 50.48% relative to using a cloud-based model for all images. In the deployed 4-class output space (Class 0-1 / Class 2 / Class 3 / Class 4), the cascade obtains 80.49% accuracy and 0.8167 quadratic weighted kappa; the cloud-only baseline obtains 80.76% accuracy and 0.8184 quadratic weighted kappa. On APTOS, the cascade cuts cloud use by about half with a modest drop in grading performance. Index Terms: Diabetic Retinopathy, Edge-Cloud Cascade, MobileNetV3-small, RETFound-DINOv2, Retinal Screening, tele-ophthalmology