Nanostructure of PEGDA-PEG hydrogel membranes and how it controls their permeability

TL;DR

This study investigates how the nanostructure and heterogeneity of PEGDA-PEG hydrogels influence their permeability, revealing that the arrangement of polymer chains controls transport properties relevant for filtration and tissue engineering.

Contribution

It combines solid-state NMR and Small Angle Neutron Scattering to elucidate the structure and dynamics of PEGDA hydrogels with added PEG chains, uncovering the role of heterogeneities in permeability.

Findings

Heterogeneities exist in both PEGDA and PEG concentrations within the hydrogels.

PEG chains entangle with the PEGDA network, affecting structure.

Permeability correlates with the specific surface of heterogeneities, following a master curve.

Abstract

The spacial heterogeneity of hydrogels composed of PEGDA and added polymer chains is expected to play a crucial role on their transport properties which can be exploited in filtration or tissue engineering. However little is known about the arrangement of the polymer chains in the matrix and the length scales of these heterogeneities. Here we combine solid-state NMR and Small Angle Neutron Scattering to unravel the structure and dynamics of PEGDA hydrogels containing added PEG chains of various concentrations. Our results show that the samples present heterogeneities in both the PEGDA and PEG concentrations and suggest that the PEG chains entangle with the PEGDA network. When plotting the sample permeability, K, as a function the specific surface of the PEGDA heterogeneities we obtain a master curve, showing that the heterogeneity of the PEGDA matrix controls the permeability of the sample. Moreover the scaling K ___ V/S suggests a structure composed of facetted PEGDA/PEG heterogeneities separated by a network of aqueous thin and flattened films in which the water can permeate.