Human-Inspired Memory Architecture for LLM Agents
Doga Kerestecioglu, Alexei Robsky, Clemens Vasters, Anshul Sharma, Yitzhak Kesselman

TL;DR
This paper introduces a biologically-inspired memory architecture for LLM agents, enhancing long-term memory management through six cognitive mechanisms and a synthetic calibration method, evaluated on two benchmarks.
Contribution
It presents a novel, biologically-grounded memory system with a calibration approach that improves memory retention and efficiency without benchmark data exposure.
Findings
Achieved 97.2% retention precision with 58% store reduction on issue-tracking data.
Matched retrieval accuracy at 70.1% with a 200K-token context budget.
Improved preference recall by 13.3 percentage points at S-tier scale.
Abstract
Current LLM agents lack principled mechanisms for managing persistent memory across long interaction horizons. We present a biologically-grounded memory architecture comprising six cognitive mechanisms: (1) sleep-phase consolidation, (2) interference-based forgetting, (3) engram maturation, (4) reconsolidation upon retrieval, (5) entity knowledge graphs, and (6) hybrid multi-cue retrieval. Each mechanism addresses a specific failure mode of naive memory accumulation. We introduce a synthetic calibration methodology that derives all pipeline thresholds without benchmark data exposure, eliminating a common source of evaluation leakage. We evaluate on two benchmarks. First, a VSCode issue-tracking dataset (13K issues, 120K events) where deduplication-based consolidation achieves 97.2% retention precision with 58% store reduction (+21.8 pp over baseline). Second, the LongMemEval…
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