Kirigami-Structured Electronic Capsule for Long-Term Continuous Gastric Monitoring
Hen-Wei Huang, Claas Ehmke, Dawei Wang, Blake Smith, Ziyao Zhou, Rong Tan, David Werder, Crystan McLymore, Niels Neidlein, Emanuele Falli, Ali Imani, James McRae, Yeseul Jeon, So-Yoon Yang, Wesley S. Culberson, James Byrne, Giovanni Traverso

TL;DR
This paper introduces a kirigami-structured ingestible electronic capsule capable of week-long gastric monitoring, featuring a bioinspired release mechanism, stable wireless communication, and safe passage, advancing long-term GI health assessment.
Contribution
The work presents a novel kirigami-enabled electronic architecture with a thermally responsive release mechanism for long-term gastric monitoring, improving stability, integration, and reliability over prior devices.
Findings
Achieved week-long gastric residence with stable telemetry.
Demonstrated safe disassembly and passage in swine.
Enabled continuous gastric radiation exposure monitoring.
Abstract
Ingestible electronic systems enable non-invasive, in situ sensing within the gastrointestinal (GI) tract, yet clinical translation has been limited by uncontrolled transit, short operational lifetimes, and unreliable wireless communication that prevent continuous monitoring. Here, we present a gastric-resident ingestible robotic platform that achieves week-long operation through integration of a bioinspired, electrically triggered release mechanism with a kirigami-enabled electronic architecture. A kirigami-patterned flexible printed circuit board spans the capsule body and deployable superelastic arms, enabling high-density integration of sensing, power management, and wireless modules within a constrained volume while tolerating large mechanical deformation during gastric residence. Stable retention and on-demand disassembly are achieved using thermally responsive polycaprolactone…
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