Analysis of persistence thresholds for a nonlocal PDE--ODE model of bacterial persister cells

TL;DR

This paper analyzes a nonlocal PDE-ODE model of bacterial persister cells, establishing conditions for colony persistence or extinction based on a sharp parameter threshold.

Contribution

It provides a rigorous mathematical analysis of the model, proving well-posedness and identifying a key threshold for bacterial colony persistence.

Findings

A sharp parameter threshold determines persistence or extinction.

Below the threshold, the washout equilibrium is globally stable.

Above the threshold, a positive equilibrium exists indicating persistence.

Abstract

Within many bacterial colonies, persister cells exist as a subpopulation that is tolerant to antibiotics and other stressors, yet not genetically distinct from the rest of the colony. A recent study has proposed epigenetic inheritance as a mechanism that leads to the presence of persister cells. We analyze a nonlocal PDE--ODE model introduced in that study to describe the epigenetic inheritance process and establish its mathematical well-posedness, including existence, uniqueness, and nonnegativity of solutions. We identify a sharp parameter threshold delineating extinction from persistence of the colony: below this threshold the washout equilibrium is globally asymptotically stable, while above it a unique positive equilibrium exists and the population is weakly persistent. Notably, this threshold is independent of the internal community structure.