Light-Adapted Electroretinogram and Oscillatory Potentials (LEOPs) Dataset for Autism Spectrum Disorder and Typically Developing Individuals

TL;DR

The LEOPs dataset offers a comprehensive collection of light-adapted ERG and oscillatory potential waveforms from children and adolescents with ASD, ASD+ADHD, and controls, facilitating research into neurophysiological differences.

Contribution

This dataset is the first to provide detailed ERG and OPs waveforms along with participant metadata for ASD and ADHD populations, enabling advanced machine learning and clinical research.

Findings

Contains over 10,000 waveforms across groups and conditions.

Includes detailed participant demographics and electrode positioning images.

Provides code and protocol files for reproducibility and further analysis.

Abstract

The LEOPs (Light-ERG-Oscillatory Potentials) dataset provides light-adapted (LA) electroretinogram (ERG) and Oscillatory Potentials (OPs) waveforms for typically developing Control, Autism Spectrum Disorder (ASD) and ASD + Attention Deficit Hyperactivity Disorder (ADHD) childhood and adolescent populations. The ERGs were recorded in the Right And Left eyes with skin electrodes using the handheld RETeval device at two sites in Australia and the United Kingdom. The LEOPs dataset includes 5309 single flash ERG and 4434 OPs waveforms as well as images selected from each participant showing the position of the skin electrode. The LEOPs dataset is constructed from recordings using a 9 step randomized flash series from $-0.37$ to $1.20$~$Td.s$, a 2 step at 113 and 446 $Td.s$ flash strengths (2500 Control, 1730 ASD and 451 ASD + ADHD samples), as well as the $85$~$Td.s$ (Light Adapted 3 $cd.s.m^{-2}$ (LA3)) equivalent International Society of Clinical Electrophysiology of Vision (ISCEV) Standard flash with 435 Control, 176 ASD and 37 ASD + ADHD waveform samples. Code for the stimulus is provided along with participant demographics, date and time of testing, and where available diagnostic scores for the ASD and ASD + ADHD groups, alongside iris color, electrode position with image files and time domain values for the ERG and summed values for the OPs. The repository contains excel file, exported JSON files on the patient level that are more suitable for machine learning tasks, images of electrode position for each recording and the protocol files for use with the RETeval.