VoDaSuRe: A Large-Scale Dataset Revealing Domain Shift in Volumetric Super-Resolution
August Leander H{\o}eg, Sophia Wiinberg Bardenfleth, Hans Martin Kjer, Tim Bj{\o}rn Dyrby, Vedrana Andersen Dahl, Anders Bjorholm Dahl

TL;DR
This paper introduces VoDaSuRe, a large-scale dataset of paired high- and low-resolution volumetric scans, revealing that current super-resolution models trained on downsampled data do not perform well on real low-resolution scans, highlighting a gap in the field.
Contribution
The authors present VoDaSuRe, the first large-scale dataset of real paired volumetric scans, and demonstrate the discrepancy between models trained on downsampled versus real low-resolution data.
Findings
Models trained on downsampled data produce sharper predictions.
Models trained on real low-resolution scans preserve structure but are less accurate.
Current SR methods are overstated when applied to real data.
Abstract
Recent advances in volumetric super-resolution (SR) have demonstrated strong performance in medical and scientific imaging, with transformer- and CNN-based approaches achieving impressive results even at extreme scaling factors. In this work, we show that much of this performance stems from training on downsampled data rather than real low-resolution scans. This reliance on downsampling is partly driven by the scarcity of paired high- and low-resolution 3D datasets. To address this, we introduce VoDaSuRe, a large-scale volumetric dataset containing paired high- and low-resolution scans. When training models on VoDaSuRe, we reveal a significant discrepancy: SR models trained on downsampled data produce substantially sharper predictions than those trained on real low-resolution scans, which smooth fine structures. Conversely, applying models trained on downsampled data to real scans…
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Taxonomy
TopicsAdvanced Image Processing Techniques · Digital Holography and Microscopy · Advanced Fluorescence Microscopy Techniques
