Entropy and Information is Transferred from Peripherical Sites to the Catalytic Sites of Enzymes

TL;DR

This study investigates how entropy and information are transferred from peripheral regions to catalytic sites in various enzymes, revealing a common trend of information flow towards the active sites.

Contribution

It provides the first comprehensive analysis of entropy and information transfer patterns across multiple enzymatic systems.

Findings

Entropy and information flow from peripherical to catalytic sites

Identified a general trend of information transfer in enzymes

Analyzed seven different enzymatic systems

Abstract

This research reports the entropy and information transfer throughout seven different enzymatic systems, namely, TIM-Barrel, Human Lysozyme, Ribonuclease A1, Pepsin , b-lactamase, Human Glucokinase and Carbonic anhydrase II. A general trend is detected: entropy and information is transported form the peripherical regions towards the catalytic site of the analyzed enzymatic systems.