Optimal control of a tumor growth model with hyperbolic relaxation of the chemical potential
Pierluigi Colli, Elisabetta Rocca, J\"urgen Sprekels

TL;DR
This paper investigates the optimal control of a tumor growth phase field model with a hyperbolic relaxation of the chemical potential, covering different potential types, and derives conditions for optimality and sparsity of controls.
Contribution
It introduces a novel hyperbolic relaxation approach in a tumor growth model and establishes differentiability and optimality conditions for control strategies.
Findings
Proves Fréchet differentiability of the control-to-state operator.
Derives first-order necessary optimality conditions.
Establishes sparsity results for optimal controls.
Abstract
In this paper, we study the optimal control of a phase field model for a tumor growth model of Cahn--Hilliard type in which the often assumed parabolic relaxation of the chemical potential is replaced by a hyperbolic one. Both the cases when the double-well potential governing the phase evolution is of either regular or logarithmic type are covered by the analysis. We show the Fr\'echet differentiability of the associated control-to-state operator in suitable Banach spaces and establish first-order necessary optimality conditions in terms of a variational inequality involving the adjoint state variables. The necessary optimality conditions are then used to derive sparsity results for the optimal controls.
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Taxonomy
TopicsSolidification and crystal growth phenomena · Mathematical Biology Tumor Growth · Nonlinear Partial Differential Equations
