Toward Clinically Ready Foundation Models in Medical Image Analysis: Adaptation Mechanisms and Deployment Trade-offs

TL;DR

This paper reviews how foundation models in medical image analysis can be adapted for clinical use, emphasizing mechanisms, trade-offs, and practical considerations for deployment and regulation.

Contribution

It introduces a framework categorizing adaptation strategies and analyzes their implications for robustness, efficiency, and regulatory compliance in clinical settings.

Findings

Five adaptation mechanisms identified and analyzed

Trade-offs between adaptation depth and robustness discussed

Guidelines for clinical deployment of foundation models provided

Abstract

Foundation models (FMs) have demonstrated strong transferability across medical imaging tasks, yet their clinical utility depends critically on how pretrained representations are adapted to domain-specific data, supervision regimes, and deployment constraints. Prior surveys primarily emphasize architectural advances and application coverage, while the mechanisms of adaptation and their implications for robustness, calibration, and regulatory feasibility remain insufficiently structured. This review introduces a strategy-centric framework for FM adaptation in medical image analysis (MIA). We conceptualize adaptation as a post-pretraining intervention and organize existing approaches into five mechanisms: parameter-, representation-, objective-, data-centric, and architectural/sequence-level adaptation. For each mechanism, we analyze trade-offs in adaptation depth, label efficiency, domain robustness, computational cost, auditability, and regulatory burden. We synthesize evidence across classification, segmentation, and detection tasks, highlighting how adaptation strategies influence clinically relevant failure modes rather than only aggregate benchmark performance. Finally, we examine how adaptation choices interact with validation protocols, calibration stability, multi-institutional deployment, and regulatory oversight. By reframing adaptation as a process of controlled representational change under clinical constraints, this review provides practical guidance for designing FM-based systems that are robust, auditable, and compatible with clinical deployment.