Initial Performance of a Long Axial FOV PET with TOF and DOI capabilities: IMAS system

TL;DR

This paper presents the design, initial performance, and first clinical results of the IMAS long axial FOV PET scanner, which uniquely combines TOF and DOI capabilities for improved total-body imaging.

Contribution

It introduces the first total-body PET system with simultaneous TOF and DOI, demonstrating promising spatial resolution and clinical tumor detection improvements.

Findings

Spatial resolution below 4 mm across the entire FOV

Coincidence time resolution of 560 ps FWHM

Enhanced tumor detection compared to conventional PET/CT

Abstract

This work summarizes the design, construction, initial performance evaluation and pilot clinical results of the IMAS system, a long axial field of view (FOV), also known as total-body (TB-), positron emission tomography (PET) prototype scanner. This PET enables for the first time in TB-PET imaging, simultaneously time-of-flight (TOF) and depth-of-interaction (DOI) capabilities. The IMAS detector block is based on LYSO semi monolithic scintillators, with individual slab sizes of 3 mm x 25 mm x 20 mm each. Arrays of 1x8 slabs are coupled to 8x8 Silicon Photomultiplier arrays. A proprietary readout reduces the 64 signals to only 16 outputs, preserving both 3D photon impact positioning and timing accuracy. IMAS has a total of 30,720 channels. PETsys electronics is used for data acquisition. The IMAS geometry is based on 5 rings of 10 cm each, with a 5 cm gap between them. It defines an axial FOV of 71 cm with a bore aperture of 82 cm. We report in this work the pilot tests of the system performance and the first clinical results. We found that the system spatial resolution remained below 4 mm across the entire FOV, even at the off-radial position of 30 cm. A coincidence time resolution with a small size 22Na source of 560 ps FWHM was measured. A sensitivity of 56.54 cps/kBq is in good agreement with previous simulation studies; however, the noise equivalent count rates performance (79 kcps at 3.26 kBq/mL) was significantly lower than expected, likely due to a data transfer bottleneck between the system and the acquisition workstation. Finally, a comparison of one of the imaged patients with a commercial TOF PET/CT scanner is also provided, pinpointing an improved tumor identification for IMAS, and the advantages of TOF and especially DOI capabilities.