OPTED: Open Preprocessed Trachoma Eye Dataset Using Zero-Shot SAM 3 Segmentation

TL;DR

The paper introduces OPTED, an open-source dataset for trachoma detection created using a zero-shot segmentation model, with a reproducible pipeline for preprocessing clinical eyelid images.

Contribution

It presents a novel, reproducible pipeline utilizing SAM 3 for automated region extraction and dataset creation for trachoma classification.

Findings

Achieved 99.5% detection rate with optimal prompt

Produced high-quality, standardized images suitable for machine learning

Released dataset and code openly for research use

Abstract

Trachoma remains the leading infectious cause of blindness worldwide, with Sub-Saharan Africa bearing over 85% of the global burden and Ethiopia alone accounting for more than half of all cases. Yet publicly available preprocessed datasets for automated trachoma classification are scarce, and none originate from the most affected region. Raw clinical photographs of eyelids contain significant background noise that hinders direct use in machine learning pipelines. We present OPTED, an open-source preprocessed trachoma eye dataset constructed using the Segment Anything Model 3 (SAM 3) for automated region-of-interest extraction. We describe a reproducible four-step pipeline: (1) text-prompt-based zero-shot segmentation of the tarsal conjunctiva using SAM 3, (2) background removal and bounding-box cropping with alignment, (3) quality filtering based on confidence scores, and (4) Lanczos resizing to 224x224 pixels. A separate prompt-selection stage identifies the optimal text prompt, and manual quality assurance verifies outputs. Through comparison of five candidate prompts on all 2,832 known-label images, we identify "inner surface of eyelid with red tissue" as optimal, achieving a mean confidence of 0.872 (std 0.070) and 99.5% detection rate (the remaining 13 images are recovered via fallback prompts). The pipeline produces outputs in two formats: cropped and aligned images preserving the original aspect ratio, and standardized 224x224 images ready for pre-trained architectures. The OPTED dataset, preprocessing code, and all experimental artifacts are released as open source to facilitate reproducible trachoma classification research.