Med-V1: Small Language Models for Zero-shot and Scalable Biomedical Evidence Attribution

TL;DR

Med-V1 is a small, 3-billion-parameter language model trained on synthetic biomedical data, achieving performance comparable to large models like GPT-5 in evidence attribution and hallucination detection tasks.

Contribution

This paper introduces Med-V1, a lightweight biomedical language model that outperforms base models and rivals larger models in evidence verification tasks.

Findings

Med-V1 outperforms base models by 27-71% on biomedical benchmarks.

Citation instructions significantly influence hallucination rates in LLMs.

Med-V1 can identify evidence misattributions in clinical guidelines.

Abstract

Assessing whether an article supports an assertion is essential for hallucination detection and claim verification. While large language models (LLMs) have the potential to automate this task, achieving strong performance requires frontier models such as GPT-5 that are prohibitively expensive to deploy at scale. To efficiently perform biomedical evidence attribution, we present Med-V1, a family of small language models with only three billion parameters. Trained on high-quality synthetic data newly developed in this study, Med-V1 substantially outperforms (+27.0% to +71.3%) its base models on five biomedical benchmarks unified into a verification format. Despite its smaller size, Med-V1 performs comparably to frontier LLMs such as GPT-5, along with high-quality explanations for its predictions. We use Med-V1 to conduct a first-of-its-kind use case study that quantifies hallucinations in LLM-generated answers under different citation instructions. Results show that the format instruction strongly affects citation validity and hallucination, with GPT-5 generating more claims but exhibiting hallucination rates similar to GPT-4o. Additionally, we present a second use case showing that Med-V1 can automatically identify high-stakes evidence misattributions in clinical practice guidelines, revealing potentially negative public health impacts that are otherwise challenging to identify at scale. Overall, Med-V1 provides an efficient and accurate lightweight alternative to frontier LLMs for practical and real-world applications in biomedical evidence attribution and verification tasks. Med-V1 is available at https://github.com/ncbi-nlp/Med-V1.