Topological analysis of bladder filling

TL;DR

This paper introduces a topological analysis method to quantify bladder structural changes during filling, revealing early remodeling signs that traditional pressure-based assessments may miss.

Contribution

The study develops a simulation-based topological framework to detect structural reorganization of the bladder during filling, providing a new quantitative approach.

Findings

Structural remodeling can be detected before functional impairment.

Geometric invariants remain stable despite surface irregularities.

Simulation results match clinical pressure and stress measurements.

Abstract

Bladder function is typically assessed through pressure volume relations, compliance indices and flow measurements, whereas structural evaluation relies largely on qualitative imaging findings. These approaches do not formally quantify how bladder geometry changes during filling. To distinguish structural reorganization from pure mechanical stiffness, we developed a simulation based topological analysis of bladder filling grounded in mechanical parameters derived from the literature. Progressive filling was modeled under quasi static conditions, generating multi volume geometries from which spatial descriptors were computed. Drawing on the Freudenthal suspension theorem, filling was interpreted as a dimensional expansion process and structural stability was evaluated by testing whether geometric invariants remain preserved across increasing volumes. Simulated smooth expansion and controlled structural perturbations were compared under identical loading conditions. Pressure trajectories and wall stress estimates were similar across configurations when compliance was matched, whereas geometric descriptors showed divergent volume indexed stability profiles in the presence of remodeling. Computable instability measures identified progressive spatial heterogeneity despite preserved global pressure behavior. By providing a quantitative measure of geometric continuity across successive filling states, our approach indicates that structural remodeling may become detectable before conventional functional impairment appears. Progressive surface irregularity can arise even when compliance, detrusor pressure and flow parameters remain within reference limits. Serial imaging over time may support identification of individuals at greater risk of diverticula formation, decompensation or structural complications despite stable pressure measurements.