Orthogonal Uplift Learning with Permutation-Invariant Representations for Combinatorial Treatments
Xinyan Su, Jiacan Gao, Mingyuan Ma, Xiao Xu, Xinrui Wan, Tianqi Gu, Enyun Yu, Jiecheng Guo, Zhiheng Zhang

TL;DR
This paper introduces a novel uplift estimation framework for combinatorial treatments that uses permutation-invariant representations and orthogonalized low-rank models, improving accuracy and stability in causal effect estimation.
Contribution
It proposes a new representation aligned with causal semantics and an orthogonalized uplift model for better estimation of combinatorial treatment effects.
Findings
Enhanced uplift estimation accuracy on large-scale data
Improved stability under policy perturbations
Robustness to nuisance estimation errors
Abstract
We study uplift estimation for combinatorial treatments. Uplift measures the pure incremental causal effect of an intervention (e.g., sending a coupon or a marketing message) on user behavior, modeled as a conditional individual treatment effect. Many real-world interventions are combinatorial: a treatment is a policy that specifies context-dependent action distributions rather than a single atomic label. Although recent work considers structured treatments, most methods rely on categorical or opaque encodings, limiting robustness and generalization to rare or newly deployed policies. We propose an uplift estimation framework that aligns treatment representation with causal semantics. Each policy is represented by the mixture it induces over contextaction components and embedded via a permutation-invariant aggregation. This representation is integrated into an orthogonalized low-rank…
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Taxonomy
TopicsAdvanced Causal Inference Techniques · Machine Learning in Healthcare · Digital Mental Health Interventions
