Hunt Globally: Wide Search AI Agents for Drug Asset Scouting in Investing, Business Development, and Competitive Intelligence

TL;DR

This paper introduces a benchmarking methodology and a specialized AI agent for comprehensive, multilingual drug asset scouting, significantly outperforming existing models in recall and precision.

Contribution

It presents a novel benchmarking approach and a tuned self-learning AI agent that achieves high recall in multilingual, heterogeneous drug asset discovery tasks.

Findings

Bioptic Agent achieves 79.7% F1 score, outperforming existing models.

Performance improves with increased compute, indicating scalability.

Constructed a challenging, real-world benchmark with expert-derived queries.

Abstract

Bio-pharmaceutical innovation has shifted: many new drug assets now originate outside the United States and are disclosed primarily via regional, non-English channels. Recent data suggests over 85% of patent filings originate outside the U.S., with China accounting for nearly half of the global total; a growing share of scholarly output is also non-U.S. Industry estimates put China at 30% of global drug development, spanning 1,200+ novel candidates. In this high-stakes environment, failing to surface "under-the-radar" assets creates multi-billion-dollar risk for investors and business development teams, making asset scouting a coverage-critical competition where speed and completeness drive value. Yet today's Deep Research AI agents still lag human experts in achieving high-recall discovery across heterogeneous, multilingual sources without hallucinations. We propose a benchmarking methodology for drug asset scouting and a tuned, tree-based self-learning Bioptic Agent aimed at complete, non-hallucinated scouting. We construct a challenging completeness benchmark using a multilingual multi-agent pipeline: complex user queries paired with ground-truth assets that are largely outside U.S.-centric radar. To reflect real deal complexity, we collected screening queries from expert investors, BD, and VC professionals, and used them as priors to conditionally generate benchmark queries. For grading, we use LLM-as-judge evaluation calibrated to expert opinions. On this benchmark, our Bioptic Agent achieves 79.7% F1 score, outperforming Gemini 3.1 Deep Think (59.2%), Gemini 3.1 Pro Deep Research (58.6%), Claude Opus 4.6 (56.2%), OpenAI GPT-5.2 Pro (46.6%), Perplexity Deep Research (44.2%), and Exa Websets (26.9%). Performance improves steeply with additional compute, supporting the view that more compute yields better results.