Convergent-Beam X-ray Crystallography

TL;DR

This paper introduces a novel X-ray convergent-beam diffraction technique using multilayer Laue lenses to obtain spatially-resolved structural information of crystals, enabling detailed analysis of strain, defects, and morphology at high resolution.

Contribution

It presents a new method for spatially-resolved crystal structure analysis using convergent-beam X-ray diffraction with high-resolution imaging capabilities.

Findings

Successfully mapped Bragg reflections into tomographic images.

Enabled high-resolution characterization of strain and defects.

Accounted for crystal morphology in structure factor determination.

Abstract

Molecular and polymeric crystals show a wide range of functional properties that arise from the interplay between the atomic-scale structure of their constituent molecules and the organization of these molecules within the crystal lattice at macroscopic length scales. X-ray diffraction can provide structural information at these disparate length scales, but usually only through experiments that address one or the other of molecular (or unit-cell) structure versus crystal structure. Consequently, the accuracy of determined molecular or polymer structures may be limited by unaccounted crystal inhomogeneities of the crystal lattice and the characterization of crystalline materials might not reveal the underlying causes of crystal morphology. Here we introduce X-ray convergent-beam diffraction to obtain spatially-resolved structural information from crystals by projection topographic imaging. Using highly focusing X-ray multilayer Laue lenses, we show that Bragg reflections can be mapped into tomographic images of the crystal, for the characterization of strain and defects at high resolution. We demonstrate how the crystal morphology obtained this way can be accounted for when determining structure factors as a function of position in the crystal. The approach may assist in studies such as diffusion and binding in MOFS, protein-drug binding, crystal growth, and the mechanical responses of photo-reactive or thermally driven dynamic crystals.