Morphological instability of an invasive active-passive interface

TL;DR

This paper models the morphological instabilities at the interface of invasive tissues and passive matrices, predicting conditions for instability development and suppression, supported by theoretical analysis and simulations.

Contribution

It introduces a continuum phase field model for active-passive tissue interfaces, predicting instability conditions and providing a phase diagram validated by simulations.

Findings

Long-wavelength instabilities can develop at tissue interfaces.

Elastic matrices suppress interface instabilities.

Simulation results align with theoretical predictions and experiments.

Abstract

Morphological instabilities of growing tissues that impinge on passive materials are typical of invasive cancers. To explain these instabilities in experiments on breast epithelial spheroids in an extracellular matrix, we develop a continuum phase field model of a growing active liquid expanding into a passive viscoelastic matrix. Linear stability analysis of the sharp-interface limit of the governing equations predicts that the tissue interface can develops long-wavelength instabilities, but these instabilities are suppressed when the active carcinoid is embedded in an elastic matrix. We develop a theoretical morphological phase diagram, and complement these with two-dimensional finite element (FEM) phase-field simulations to track the nonlinear evolution of the interface with results consistent with theoretical predictions and experimental observations. Our study provides a basis for the emergence of interfacial instabilities in active-passive systems with the potential to control them.