Chiral phase memory of twisted light through multiple scattering

TL;DR

This paper demonstrates that topological phase observables in twisted light can encode molecular chirality and survive multiple scattering, enabling robust chiroptical sensing in turbid media where traditional signals are suppressed.

Contribution

It introduces a method to preserve chiral phase information using twisted light's topological structure through scattering media, surpassing limitations of conventional chiroptical signals.

Findings

Chiral phase memory persists at high scattering levels.

Azimuthal rotation encodes molecular handedness.

Differential measurements isolate chiral signals effectively.

Abstract

Chiroptical signals, optical responses sensitive to molecular handedness, are rapidly suppressed by multiple scattering, fundamentally limiting their use in turbid media. Here we show that coupling molecular chirality to the topological structure of twisted light generates a protected phase observable that survives strong scattering. When Laguerre-Gaussian beams carrying orbital angular momentum propagate through chiral media, spin-orbit interaction converts circular birefringence into an azimuthal rotation of the helical wavefront. Remarkably, this chiral phase memory persists at scattering strengths that fully depolarize conventional beams, with the rotation magnitude preserved quantitatively between transparent solutions and strongly scattering tissue. The sign of the azimuthal rotation encodes molecular handedness: opposite enantiomers produce mirror-symmetric phase maps even after multiple scattering. Differential measurements between conjugate topological charges isolate the chiral contribution while cancelling achiral background, enabling the resolution of refractive-index changes of order 10-6. These results establish topological phase observables as robust carriers of weak chiral light-matter interactions in complex media, opening new routes for chiroptical spectroscopy and sensing beyond the ballistic-photon regime.