Data-Driven Uniform Inference for General Continuous Treatment Models via Minimum-Variance Weighting
Chunrong Ai, Wei Huang, Zheng Zhang

TL;DR
This paper introduces a nonparametric, data-driven method for estimating general continuous dose-response functions using minimum-variance weights, providing uniform confidence bands and demonstrating effectiveness through simulations and real data.
Contribution
It develops a stable, closed-form weighting scheme for nonparametric dose-response estimation, enabling efficient inference with uniform confidence bands.
Findings
Weights have minimum sample variance.
Uniform confidence bands are valid and data-driven.
Method performs well in simulations and real data applications.
Abstract
Ai et al. (2021) studied the estimation of a general dose-response function (GDRF) of a continuous treatment that includes the average dose-response function, the quantile dose-response function, and other expectiles of the dose-response distribution. They specified the GDRF as a parametric function of the treatment status only and proposed a weighted regression with the weighting function estimated using the maximum entropy approach. This paper specifies the GDRF as a nonparametric function of the treatment status, proposes a weighted local linear regression for estimating GDRF, and develops a bootstrap procedure for constructing the uniform confidence bands. We propose stable weights with minimum sample variance while eliminating the sample association between the treatment and the confounding variables. The proposed weights admit a closed-form expression, allowing them to be computed…
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Taxonomy
TopicsStatistical Methods in Clinical Trials · Advanced Causal Inference Techniques · Advanced Radiotherapy Techniques
