On the Palindromic/Reverse-Complement Duplication Correcting Codes

TL;DR

This paper develops new error-correcting codes for DNA storage that can handle reverse-complement and palindromic duplications, providing explicit constructions, bounds, and efficient algorithms.

Contribution

It introduces explicit codes for correcting duplications with minimal redundancy and analyzes bounds, advancing DNA storage error correction methods.

Findings

Constructed codes with a single redundant symbol correcting multiple duplications.

Derived a Gilbert-Varshamov bound for duplication-correcting codes.

Presented two explicit codes for correcting length-one reverse-complement duplications.

Abstract

Motivated by applications in in-vivo DNA storage, we study codes for correcting duplications. A reverse-complement duplication of length $k$ is the insertion of the reversed and complemented copy of a substring of length $k$ adjacent to its original position, while a palindromic duplication only inserts the reversed copy without complementation. We first construct an explicit code with a single redundant symbol capable of correcting an arbitrary number of reverse-complement duplications (respectively, palindromic duplications), provided that all duplications have length $k \ge 3\lceil \log_q n \rceil$ and are disjoint. Next, we derive a Gilbert-Varshamov bound for codes that can correct a reverse-complement duplication (respectively, palindromic duplication) of arbitrary length, showing that the optimal redundancy is upper bounded by $2\log_q n + \log_q\log_q n + O(1)$. Finally, for $q \ge 4$, we present two explicit constructions of codes that can correct $t$ length-one reverse-complement duplications. The first construction achieves a redundancy of $2t\log_q n + O(\log_q\log_q n)$ with encoding complexity $O(n)$ and decoding complexity $O\big(n(\log_2 n)^4\big)$. The second construction achieves an improved redundancy of $(2t-1)\log_q n + O(\log_q\log_q n)$, but with encoding and decoding complexities of $O\big(n \cdot \mathrm{poly}(\log_2 n)\big)$.