Quantum Sensing MRI for Noninvasive Detection of Neuronal Electrical Activity in Human Brains

TL;DR

This paper introduces quantum sensing MRI (qsMRI), a novel noninvasive technique using quantum sensors to directly detect neuronal magnetic fields in the human brain, potentially revolutionizing functional neuroimaging.

Contribution

The paper presents the first application of quantum sensing in human MRI, enabling direct measurement of neuronal activity with high spatial and temporal resolution.

Findings

qsMRI successfully detects neuronal magnetic fields in simulations and human studies

The method can differentiate brain activity during rest and motor tasks

Open procedures facilitate independent validation of the technique

Abstract

Neuronal electrical activity underlies human cognition including perception, attention, memory, language, and decision-making. Yet its direct, noninvasive measurement in the living human brain remains a fundamental challenge. Existing neuroimaging techniques, including electroencephalography (EEG), magnetoencephalography (MEG), and functional magnetic resonance imaging (fMRI), are limited by trade-offs in sensitivity and spatial or temporal resolution. Here we propose quantum sensing MRI (qsMRI), a noninvasive approach that enables direct detection of neuronal firing-induced magnetic fields using a clinical MRI system. qsMRI exploits endogenous proton (1H) nuclear spins in water molecules as intrinsic quantum sensors and decodes time-resolved phase information from the free induction decay signals to infer neuronal magnetic fields. We validate qsMRI through simulations, phantom experiments, and human studies at rest and during motor tasks, and provide open experimental procedures to facilitate independent rigorous validation. We further present a case study demonstrating potential applications to neurological disorders. qsMRI represents, to our knowledge, the first-in-human application of quantum sensing on a clinical MRI platform and may lay the foundation for a non-BOLD functional imaging modality capable of probing neuronal firing dynamics in both cortical and deep brain regions.