Co-doping of silicate bioceramics as a potential strategy to further enhance mono-doping consequences

TL;DR

This review explores how co-doping silicate bioceramics can enhance their biological functionalities for medical applications, emphasizing chemical interactions and future research directions.

Contribution

It highlights the potential of dual or multiple co-doping strategies to improve silicate bioceramics beyond mono-doping effects, with a focus on chemical interactions and future prospects.

Findings

Co-doping can synergistically enhance osteogenesis, angiogenesis, and antibacterial activity.

Chemical interactions among co-dopants influence bio-behavior of bioceramics.

Future in vivo studies and clinical trials are crucial for commercialization.

Abstract

Silicate bioceramics have attracted significant attention in medical applications, particularly in hard tissue regeneration, because of their controllable chemical, physical, and biological functionalities, while ensuring biocompatibility. The coordination of silicate bioceramics with mono-dopants has been extensively studied to enhance their osteogenesis, angiogenesis, and antibacterial activity. However, the concept of employing dual or multiple co-doping to further enhance these biomaterials still demands more attention. This review paper originally focuses on the effect of chemical interactions among co-dopants and the principal constituents of the silicates, on the bio-behavior of these bioceramics. Additionally, future prospects of co-doped silicate bioceramics are outlined, including in vivo studies, clinical trials, and potential commercialization.