Fluoride doping into SiO2-MgO-CaO bioactive glass nanoparticles: bioactivity, biodegradation and biocompatibility assessments

TL;DR

This study investigates how fluoride doping affects the structure, bioactivity, biodegradation, and biocompatibility of SiO2-MgO-CaO bioactive glasses, revealing optimal fluoride levels for enhanced biological performance.

Contribution

It is the first to systematically analyze fluoride doping effects on SiO2-MgO-CaO glasses' bioactivity and biocompatibility using comprehensive in vitro assessments.

Findings

Optimal fluoride level enhances bioactivity.

Fluoride improves biocompatibility with osteoblast-like cells.

Amorphicity and fluoride incorporation confirmed by XRD and Raman.

Abstract

In this research, for the first time, the structure, bioactivity, biodegradation and biocompatibility of SiO2-MgO-CaO glasses doped with different levels of fluoride were studied. The glassy powder samples were synthesized by a coprecipitation method followed by calcination at 500 C, where amorphicity and fluoride incorporation were verified by X-ray diffraction and Raman spectroscopy, respectively. The in vitro biomineralization and biodegradation of the samples were also investigated by electron microscopy, Raman spectroscopy and inductively coupled plasma optical emission spectrometry. These assessments revealed that there is an optimum level of fluoride doping to meet the highest bioactivity. Remarkably, the same level of incorporation presented the foremost biocompatibility with respect to osteoblast-like MG-63 human cells, as realized by the MTT assay and cell attachment studies.